Pathologies auto-immunes Flashcards

1
Q

Quel est le dosage de dépistage des maladies auto-immunes systémiques ?

A

Anticorps anti-nucléaire

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2
Q

Technique pour analyser les AAN ?

A

Immuno-fluorescence indirecte (IFI) sur cellules Hep2

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3
Q

Aspect en fluorescence

–> Homogène ?

A

• AA non solubles

  • -> Anti-DNA natif (en périphérie)
  • -> Anti-histone
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4
Q

Aspect en fluorescence

–> Moucheté ?

A

• AA solubles = Anti-ENA

  • -> Anti-Sm
  • -> Anti-SSA
  • -> Anti-SSB
  • -> Anti-RNP
  • -> Anti-Scl70
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5
Q

Aspect en fluorescence

–> Nucléolaire ?

A

• AA solubles = Anti-ENA

–> Anti-centromère

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6
Q

VoF les anticorps Anti-DNA natif sont spécifiques du Lupus ?

A

VRAI

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7
Q

Techniques pour analyser les Anti-DNA natif ? (3)

A
  • Test de Farr (très spécifique)
  • Test IFI sur Crithidia Luciliae
  • Test ELISA
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8
Q

Techniques pour analyser le Facteur rhumatoïde ?

A
  • Test au Latex

* Réaction de Waaler-Rose

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9
Q

Maladie auto-immune

–> Ac anti-mitochondries ?

A

Cirrhose biliaire primitive

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10
Q

Maladie auto-immune

–> Ac Anti-muscles lisses ?

A

Hépatites auto-immunes

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11
Q

Pathologies ou l’ont retrouve des AAN ?

A
  • Lupus
  • PR
  • Goujerot
  • Sclérodermie
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