Pathogenisi Flashcards
Mutoalisim bacteria
Lactic acid bacteria
Commonsalisim bacteria
Staphylococcus epidermis
Opportunistic
Microorganisim rarely caused disease but cause a serious infection in immunocompromised patient (parasites/normal flora)
Virulence
The degree of pathogenicity, quantitive measure by the number of microorganisms recuired to cause disease
Potential pathogenesis(opportunistic)
-s.pneumonia
-s.epedermis
-h.influenzae
Commensal/parasite without disease
Obligate pathogenesis
Organisim can’t survive along without a host to cell cycle
Obligate intracellular
Bacteria can grow just within host cells
Chlamydia/ricktessiae
Facultative parasite
Bacteria growth inside/outside host cells or in bacteriomedia
What is the important factors determine the infection
1-the number of microorganisim in host
2-pathogen virulence
3-the virulence factors (endotoxin type/capsule/pilli…)
Non-communicable bacteria
Botulisim , produce exotoxin in the food
Communicable bacteria
Tuberculosis by coughing
What cause the invasive bacteria
Induce inflammatory cells and cause redness(erythema)/warmth/edema/pain
Bacteria in Chronic carrier state
Typhoid mary
Growth the microorganism and cause infection with or without symptoms
Transplacental pathogens
1-cytomegalovirus 2-barvovirus 3-treponema pallidum 4-toxoplasma gondi 5-listeria
Canal birth during birth pathogen
1-herpes simplex 2 virus 2-hepatinic b virus 3-human immunodeficiency virus 4-candia albecans 5-chlamydia 6-esharichea 7-streptococcus group b
Breast milk pathogen
1-s.aureus
2-cytomegalovirus
3-human t-cell leukemia virus
Bacteria transmitted by ticks
Borrelia (lyme disease)
Riktissea (rocky mountain fever)
The symptoms of lyne disease
Fever
Fatigue
Headache
Erythema migrans
The important portals to entry pathogens
- gastrointestinal tract
- respiratory tract
- skin
- genital tract
What is the bactria adherence in urinary tract epithelium and what is the adhesions structure
N.gonorhoae and e.coli by pilli
What is Bactria adherence in endothelial valve and what is the adhesins structure
Staphylococcus epidermis/varidans
Glycosalyx
Which of bacteria persists in lungs of cystine fibrosis patient ,by which virulence factor
Pseudomonas bacteria by forming biofilms
Quorum sensing
Bacteria grow with nonaggressive manner until to reach to specific density to form virulence factors and be pathogen (like pseudomonas when form biofilms)
What means in curli, and what do in body
Curli is the surface of protiens binding bacteria with endothelial and ECM (fibronicten)
Interaction with coagulation factor and produce thrombus (dissiminated intravascular coagulation)
In e.coli/salmonella
Bacteria formed collagenase/ hyaluronidase
S.pyogenes
Bacteria produce coagulase
S.aureus
Bacteria produce IGA protease
H.influinza
N.gonorhoae
S.pneumonia
Antiphagocytic factors
1-capsule
2- M-protien , found in gram+ cocci in cell wall (group A s.pyogens)
3-A-protein , found in s.aureus