Pathogenesis of Psychiatric Disorders

Question 1

Precautions with Asians and antipsychotics

Answer 1

they require 1/2 to 1/3 dose because P450 mutations: slow metabolizers of meds

Question 2

genetics with schizophrenia

Answer 2

1/2 environmental and 1/2 genetic; high family risk

Question 3

genetics of MDD

Answer 3

1/3 genetic 2/3 enviornment; high family risk; Asians require a lower dose of antidepressants
may have mutation in SERT

Question 4

Genetics of Bipolar D/O

Answer 4

strong genetic influence; very rare if they do not have family member with dx;

Question 5

Genetics with panick d/o

Answer 5

strong genetic risk plus trauma in childhood; mutations with SERT

Question 6

genetics with ADHD

Answer 6

high family hx;

Question 7

genetics of OCD

Answer 7

group A strep may cause onset OCD in hcildren (PANDASP;

Question 8

genetics of alcohol and addiction

Answer 8

strong genetic and environment influence; Asians produce higher acetaldhyde when drinking alcohol which causes flushing, palpitations, women tend to produce less/metabolize slower therefore have higher level than men

Question 9

genetics in AD

Answer 9

genetic and environmental influences; family hx with first degree relative;

Question 10

genetics of Autism

Answer 10

high genetic 90%; children tend to have inherited the thymine rather than adenine variant of a certain chromosome

Question 11

Genetics of eating d/o

Answer 11

genetics and environment: 11 times higher risk in families than general population; can have variation of gene responsible for Ghrelin hormone that stimulates appetite in stomach and intestine