Pathogenesis of Parasitic infections

Question 1

What are the three species of Schisosomiasis ?

Answer 1

Schistosoma mansoni
S.,haematobium
S.japonicum

Question 2

Outline the life cycle of Schistosomiasis

Answer 2

SLIDE

Question 3

What happens following exposure to Schistosomiasis ?

Answer 3

Cercarial dermatitis

Exposure to cercariae from animal or bird schistosomes

Requires pre-sensitisation

Allergic-type reaction

Question 4

What is the key feature of the immune response to Schistosomiasis ?

Answer 4

Granuloma formation
Eggs become organised in granulomas

Repeated insults and tissue repair leads to fibrosis and organ damage
(liver or bladder )

Question 5

What occurs in hepato-intestinal schistosomiasis ?

Answer 5

The eggs are pushed through the capillaries into the lumen of the intestines.

This can lead to cirrhosis and long term damage
Enlargement of liver and spleen