Mechanisms of viral infection and pathogenesis

Question 1

What is the general patterns of viral infection ?

Answer 1

Acute infection

This is when we are infected, has a limited life span ,disease symptoms tend to correspond to the peak

Question 2

What are some examples of acute infections ?

Answer 2

Measles
Common cold
Ebola
Small pox

Question 3

What are chronic infections?

Answer 3

The course of the viral infection lasts much longer

Latent reactivating infection
-Symptoms , then resolved Virina and it causes waves

Persistent infection

Question 4

What are some examples of latent/reactivating infections ?

Answer 4

Human herpes viruses

Life long infection ,controlled by immunity

Question 5

What does Herpes cause in humans ?

Answer 5

In children :
Primary gingivostomatitis

In adults :
Cold sore

Question 6

Outline the course of herpes simplex /VZV latency

Answer 6

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Question 7

What are persistence infections ?

Answer 7

Persistence in the precense of an active immune response

HIV-Retrovirus
HCV-flavivirus

Measles -Causes acute infection , but virus shed for several weeks after acute infection and rare encephalitis cases years after infection

Question 8

What are some examples of persistant infections ?

Answer 8

Congenital Rubella
If infected in utero, virus is seen as self , babay is born immunotolerant and virus will continue to replicate and cause damaged in neonatal tissues)

Question 9

What is congenital rubella ?

Answer 9

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