pathogenesis

Question 1

in order to cause damage

Answer 1

violence must be expressed and a strict pathogen is high in this

Question 2

what are the 6 pathogen steps

Answer 2

1. entry
2. colonize
3. multiply
4. spread
5. toxicity
6. outcomes

Question 3

entry

Answer 3

adhesion factors such as tissue specificity and host specificity

Question 4

Bordetella pertussis causes

Answer 4

whooping cough

Question 5

what is in the lipid bilayer

Answer 5

phospotases

Question 6

what are some types of enzyme

Answer 6

hyladroidase = breaks down hylaronic acid – pnemoicocci and strep
colloenases - gas gangrene
coagulase- strep pyrogens - strep throat

Question 7

exotoxins

Answer 7

are more specific

Question 8

endotoxins

Answer 8

are more general

Question 9

what are three types of exotoxins

Answer 9

1. AB
2. Cytolytic toxins
3. super antigens

Question 10

fluid in the lumen leads to

Answer 10

diarehia

Question 11

TSSTI is caused by

Answer 11

stap aureus

Question 12

diphteria toxin

Answer 12

caused by corny bacterium diphtheria it is an AB toxin

** disrupts EF-2 and interferes with protien synthesis

Question 13

Tetanus and Botulinum toxins

Answer 13

strict anaerobes in sol and are spore forms
tetanus - from c retain and can cause neurological impairment

botulism= cause muscle paralysis

Question 14

what happens in botulism

Answer 14

acetylcolone is blocked and glycine controls the release

** if tetanus then continuous contraction and acetyl colone

Question 15

enterotoxins

Answer 15

in the GI tract and cause secretion of fluid in to the lumen and it is caused by cloeria toxin

Question 16

what is happening in a enterotoxin?

Answer 16

GM1 ganglioside receptor  cAMP  increase in K, Na, Bicarbonate and water
Quorum sensing (when to block adhesion)  communicating cell to cell communication  make biofilms —– V.Cholera down regulates
Smooth vs Rough  eps former

Question 17

endotoxin

Answer 17

cause physiological effects - fever
they have to do with lipid A

Example of virulence factors  salmonella
Virulence  anything that causes damage to the host