pathogenesis Flashcards
in order to cause damage
violence must be expressed and a strict pathogen is high in this
what are the 6 pathogen steps
- entry
- colonize
- multiply
- spread
- toxicity
- outcomes
entry
adhesion factors such as tissue specificity and host specificity
Bordetella pertussis causes
whooping cough
what is in the lipid bilayer
phospotases
what are some types of enzyme
hyladroidase = breaks down hylaronic acid – pnemoicocci and strep
colloenases - gas gangrene
coagulase- strep pyrogens - strep throat
exotoxins
are more specific
endotoxins
are more general
what are three types of exotoxins
- AB
- Cytolytic toxins
- super antigens
fluid in the lumen leads to
diarehia
TSSTI is caused by
stap aureus
diphteria toxin
caused by corny bacterium diphtheria it is an AB toxin
** disrupts EF-2 and interferes with protien synthesis
Tetanus and Botulinum toxins
strict anaerobes in sol and are spore forms
tetanus - from c retain and can cause neurological impairment
botulism= cause muscle paralysis
what happens in botulism
acetylcolone is blocked and glycine controls the release
** if tetanus then continuous contraction and acetyl colone
enterotoxins
in the GI tract and cause secretion of fluid in to the lumen and it is caused by cloeria toxin
what is happening in a enterotoxin?
GM1 ganglioside receptor cAMP increase in K, Na, Bicarbonate and water
Quorum sensing (when to block adhesion) communicating cell to cell communication make biofilms —– V.Cholera down regulates
Smooth vs Rough eps former
endotoxin
cause physiological effects - fever
they have to do with lipid A
Example of virulence factors salmonella
Virulence anything that causes damage to the host
