Pathogenesis Flashcards
Pathogenesis
● Initial Lesion = PMNs
o Develops in 2 to 4 days
o Cells of acute inflammation present
o Increased GCF flow
o Start of pseudopocket formation
▪ Acute = PMNs
● Early Lesion = T-Cell lesion
o Early lesion occurs after 4-7 days
o Acute inflammation persists (from initial lesion), increased GCF, pseudopocket formation
o Cells of chronic inflammation appear and then dominate
o Collagen loss up to 70%*
o Rete pegs proliferation of JE into CT
o Loss of gingival stippling
● Established Lesion
o Shift to a B-cell/Plasma Cell lesion
o Micro-ulcerations of pocket/sulcular epithelium 🡪 bleeding on probing
▪ BOP means pt is in the established lesion phase of gingivitis
o Erythema
o Bleeding on probing (BOP)
o Gingival changes: color, contour, consistency
o No bone loss
● Advanced Lesion = PERIODONTITIS
o Pocket formation
▪ PDL destruction
▪ Apical migration of JE
▪ Bone resorption/loss
o Loss of fiber attachment – Cementum and PDL
o B-Cells, plasma cells dominate