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Perio 1 2020 > Pathogenesis 10/5/16 > Flashcards

Pathogenesis 10/5/16 Flashcards

1
Q

Is IL-1B high or low in disease?

A

High

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2
Q

Is IL-4 high or low in disease?

A

Low

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3
Q

Is IL-10 high or low in disease?

A

Low

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4
Q

Is TNF-a high or low in disease?

A

High

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5
Q

IS IL-1ra high or low in diesease?

A

Low

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6
Q

Is INF-g high or low in disease?

A

High

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7
Q

Is PGE2 high or low in disease?

A

High

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8
Q

Is MMPs high or low in disease?

A

High

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9
Q

Is TGF-b high or low in disease?

A

Low

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10
Q

Are TIMPs high or low in disease?

A

Low

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11
Q

What type of cytokine do you find in GFC?

A

IL-1 alpha and beta

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12
Q

What does IL-1 alpha and beta activate?

A

CD4

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13
Q

What interleukin is secreted by CD4 and NK cells?

A

-IL-2 alpha and beta

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14
Q

What interleukin enhances the production of IgA?

A

IL-5

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15
Q

What cytokine activates osteoclasts leading to bone resorption?

A

TNF alpha and beta

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16
Q

Is IL-1B proinflammatory or anti-inflammatory?

A

Proinflammatory

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17
Q

Is TNF alpha proinflammatory or anti-inflammatory?

A

Proinflammatory

18
Q

Is TGF-b proinflammatory or anti-inflammatory?

A

Anti-Inflammatory

19
Q

Is IL-1ra proinflammatory or anti-inflammatory?

A

Anti-inflammatory

20
Q

Is IL-10 pro or anti inflammatory?

A

Anti

21
Q

Is IFN-gamma Pro or anti inflammatory?

A

Pro

22
Q

Is PGE2 pro or anti inflammatory?

A

Pro

23
Q

Is IL 4 pro or anti inflammatory?

A

Anti

24
Q

Are MMPs anti or pro inflammatory?

A

Pro

25
Q

Are TIMPs pro or anti inflammatory?

A

Anti

26
Q

Is anti or pro inflammatory protective?

A

Anti

27
Q

What is the primary proteinases involved in periodontal tissue degradation?

A

MMP

28
Q

What do MMPs degrade?

A
  • collagen
  • gelatin
  • elastin
29
Q

What inhibits MMPs?

A

modified tetracycline

30
Q

What does arachidonic acid do to the vasopermeability and vasodilation?

A

Increases

31
Q

What does arachidonic acid do to MMP secretion by monocytes and fibroblasts?

A

Induces them

32
Q

T/F

Arachidonic Acid is not increased in gingivitis and periodontal disease

A

False

It is increased

33
Q

What breaks down arachidonic acid?

A

COX 1/2

34
Q

What type of people do you find high levels of arachidonic acid in?

A

Type II diabetics

35
Q

How do you inhibit PGE2 synthase from making PGE2?

A

NSAIDs

36
Q

What are three cytokines that can upregulate monocyte PGE2 secretion?

A
  • TNF alpha
  • IL-1b
  • GM-CSF
37
Q

What systemic factors can lead to more periodontitis?

A
  • Host stress
  • Physical stress
  • Social effectors
  • Environmental stress
38
Q

Host stress will release what neuropeptide?

A

Corticotropin releasing factor (CRF)

39
Q

When CRF is released what does that lead to the release of?

A

IL-1

TNF-a

40
Q

What does TNF-1 and IL-1 lead to?

A

Periodontitis

Perio 1 2020 (9 decks)

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