Patho Lab Flashcards
What is the grade of Diffuse astrocytoma?
Grade 2
What is the grade of Oligodendroglioma?
Grade 2
What is the grade of Meningioma?
Grade 1
What is the grade of Ependymoma?
Grade 2
What is the grade of Medulloblastoma?
Grade 4
List two histological features of Diffuse astrocytoma.
- Increased cellularity
- Atypical nuclei
List two histological features of Oligodendroglioma.
- Atypical nuclei + perinuclear halo
- Chicken-wire vvs
List two histological features of Meningioma.
- Epithelioid cell + indistinct CM
- Whorl +/- Psammoma bodies
List two histological features of Ependymoma.
- Increased cellularity
- Rosettes (Perivascular +/- True)
What type of cells are characteristic of Medulloblastoma?
Small blue round cells
What mutation is associated with better prognosis in tumors?
IDH-mutant
What is the prognosis for IDH-wildtype tumors?
Rare
Where are Diffuse astrocytomas commonly located in adults?
Supratentorial esp. frontal
What genetic markers are associated with better prognosis in Oligodendroglioma?
IDH-mutant + 1p/19q codeleted
Where are Ependymomas commonly located?
Ependymal-lined areas
What is a common location for Medulloblastoma in children?
Posterior fossa esp. cerebellum
True or False: Meningiomas are often associated with NF2.
True
Fill in the blank: Ependymomas are common in _______ to adults.
Children
