patho case 5: joints Flashcards
what is another name for solid joint
synarthroses
what disease is characterized by degeneration of cartilage that results in structural and functional failure of synovial joints
osteoarthritis
what is the most common type of joint disease
osteoarthritis
what is collagen type 2 degraded by in osteoarthritis
matrix metalloproteinase
what are the major environmental factors associated with osteoarthritis
age and biomechanics stress
what happens to the water content and concentration of proteoglycans in early stages of osteoarthritis
water content increases and proteoglycans decrease
what disease does heberden nodes occur in
osteoarthritis
how might CD4+ T helper cells initiate the autoimmune response in RA
by reacting with arthritogenic agent
what does IFN game do in RA
activates macrophages and residence synovial cells
what does IL17 from Th17 cells do in relation to RA
recruits neutrophils and monocytes
what does TNF and IL-1 do in respect to RA
stimulates resident synovial cells to secrete proteases that destroy hyaline cartilage
what does RANKL expressed on activated T cells due respect to RA
stimulates bone resorption
what cytokine has been most firmly impacted in the pathogenesis of RA
TNF
what does RA principally affect
the small joints of the hands and feet
what is the term that is a mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts that grows over the articular cartilage and causes its erosion
pannus
