genetics chapter 9

Question 1

what chromosome is the immunoglobulin heavy chain on

Answer 1

14q32

Question 2

what chromosome is the immunoglobulin k light chain on

Answer 2

2p13

Question 3

what chromosome is the immunoglobulin lambda light chain on

Answer 3

22q11

Question 4

what chromosome is the T cell receptor alpha on

Answer 4

14q11

Question 5

what chromosome is the T cell receptor beta on

Answer 5

7q35

Question 6

what chromosome is the T cell receptor gamma on

Answer 6

7p15

Question 7

what chromosome is the T cell receptor delta on

Answer 7

14q11

Question 8

what chromosome is the beta2-microglobulin on

Answer 8

15q21-22

Question 9

what chromosome are RAG1 and RAG2 on

Answer 9

11p13

Question 10

what is the associated MHC allele for type 1 diabetes

Answer 10

DQB1*0302

Question 11

what is the associated MHC allele for ankylosing spondylitis

Answer 11

B27

Question 12

what is the associated MHC allele for narcolepsy

Answer 12

DR2 and DQA1, DQB1

Question 13

what is the associated MHC allele for celiac disease

Answer 13

DR3, DR7

Question 14

what is the associated MHC allele for RA

Answer 14

DR1, DR4

Question 15

what is the associated MHC allele for myasthenia gravis

Answer 15

DR3, DR7

Question 16

what is the associated MHC allele for MS

Answer 16

DR2

Question 17

what is the associated MHC allele for pemphigus vulgaris

Answer 17

DR4

Question 18

what is the associated MHC allele for SLE

Answer 18

DR3

Question 19

what is the associated MHC allele for hemochromatosis

Answer 19

A3

Question 20

what is the associated MHC allele for malaria

Answer 20

B53

Question 21

what is the associated MHC allele for graves disease

Answer 21

DR3

Question 22

what is the associated MHC allele for psoriasis vulgaris

Answer 22

Cw6

Question 23

what is the associated MHC allele for squamous cell cervical carcinoma

Answer 23

DQw3

Question 24

what is the condition with absence of B cells that leads to recurrent bacterial infections

Answer 24

X-linke agammaglobulinemia

Question 25

what is the condition with T-cell deficiency leading also to impairment of humoral immune responses; fatal unless treated by bone marrow transplantation or gene therapy

Answer 25

SCID

Question 26

what is the condition with a protein kinase deficiency leading to T-cell and B-cell deficiency

Answer 26

SCID due to Jak3 deficiency

Question 27

what condition is the lack of recombinase activity impairing VDJ impairment, leading to B cell and T cell deficiency

Answer 27

SCID due to rAG1 or RAG2 deficiency; Omenn syndrome

Question 28

what is the T cell deficiency that leads to impaired B cell response

Answer 28

SCID due to IL-7 alpha chain deficiency

Question 29

what condition is due to lack of CTLs; defective Th cells; impaired antibody response

Answer 29

Zap70 kinase deficiency

Question 30

what condition has deficiency MHC1 expression that leads to T cell and B cell deficiency

Answer 30

BLS

Question 31

what condition has congenital malformations that include abnormal facial features, congenital heart disease, and thymus abnormality leading to T cell deficiency

Answer 31

DiGeorge anomaly

Question 32

what condition has DNA repair defect characterized by unsteady gate, telangiectasia, and thymus abnormality producing T cell deficiency

Answer 32

ataxia telangiectasia

Question 33

what condition is described by abnormal, small platelets, eczema, and abnormal T cells causing susceptibility to opportunistic infections

Answer 33

wiskott-aldrich syndrome

Question 34

what condition is described by partial albinism, defective lysosomal assembly, giant cytoplasmic granules, abnormal NK cells and neutrophils leading to recurrent bacterial infections

Answer 34

chediak-higashi syndrome

Question 35

what condition is described by mutations in intern receptor gene produce phagocytes that cannot recognize and ingest microorganisms, resulting in severe bacterial infections

Answer 35

leukocyte adhesion deficiency