patho- blood disorders

Question 1

proportion of RBC in blood

Answer 1

hematocrit

Question 2

Insufficient iron impairs hemoglobin synthesis

Answer 2

iron deficiency anemia

Question 3

pernicious anemia (b12)

Answer 3

Characterized by very large, immature, nucleated erythrocytes (megaloblasts – unusually large erythroblasts)
due to deficiency of vitamin b12 (lack of intrinsic factor)

Question 4

diagnostic tests for pernicious anemia

Answer 4

microscopic exam of erythrocytes
bone marrow exam (hyperactive, increased # of megaloblasts
B12 serum levels

Question 5

Aplastic anemia

Answer 5

failure or impairment of bone marrow

CBC indicates pancytopenia

Question 6

hemolytic anemia

Answer 6

results from excessive destruction of RBC’s

-sickle cell, infection (malaria), immune reactions

Question 7

thalassemia

Answer 7

genes for some hemoglobin chains are mutated or missing

-abnormal Hb=RBC hemolysis

Question 8

polycythemia

Answer 8

increased production of RBC

-increased blood volume and viscosity results

Question 9

which type of leukemia has a high proportion of immature blasts in bone marrow and circulation

Answer 9

acute

Question 10

which type of leukemia has a high proportion of mature cells with reduced function

Answer 10

chronic

Question 11

precursors of lymphocytes (granulocytes) affected

Answer 11

lymphocytic leukemia

Question 12

precursors of granulocytes affected

Answer 12

myelogenous leukemia