Path Of Breast 2

Question 1

Genetic lesions of breast cancer ?

Answer 1

HER/NEU 2 gene
++in estrogen receptor gene
- - in tumor suppressor gene p53
BRCA1 and BRCA2

Question 2

Non invasive breast carcinoma of ductal carcinoma in situ (DCIS)

Answer 2

Fill duct spaces, rarely manifests as palatable has excellent prognosis

Question 3

Cause of pagets disease ?

Answer 3

Caused by extension of DCIS in lactoferous ducts into nipple and skin causing eczema like lesion on nipples and aerola

Question 4

What is Medullary carcinoma

Answer 4

Is invasive ductal carcinoma that has anaplastic sheets, lack estrogen and progesterone receptors and don’t express HER/NEU2 gene

Question 5

Tubular carcinoma

Answer 5

Ductal invasive carcinoma that is less that one centimeter, and show malignant ductal cells arranged in tubules, which has excellent prognosis

Question 6

Infiltrating ductal carcinoma ?

Answer 6

Nipple retraction, firm, peu d’orange, palpated axillary lymph nodes. Star shape

Question 7

Inflammatory carcinoma ?

Answer 7

Swollen erythematous breast which involve dermal lymphatics and usually metastasize

Question 8

Invasive lobular carcinoma ?

Answer 8

Rarely express HER/NEU 2 gene, palpable, INDIAN FILE sheets

Question 9

All specialized type tubular and medullary and mucinous invasive ductal carcinoma show

Answer 9

Show excellent prognosis except inflammatory

Question 10

Overexpression of her/neu 2 gene

Answer 10

Poorest prognosis with treatment of trastuzumab to show response