Past Questions Flashcards
What dictiates the biological function of heparan sulphide?
Level and sulphation patterns of the way it’s attached to the core protein
Levels and sulphation pattern
What is the key feature of hodgekins syndrome lymphoma as opposed to non-hodgekins
Presence of Reed-Sternberg cells (mature malignant B-lymphocytes) (multinucleated or bi-lobed)
True or false: MPS 1 Hurlers is an autosomal dominant inherited disease
False: autosomal recessive
What is aneuploidy
Abnormal amount of chromosomes
In histology, how would you test for presence of acid-fast bacilli for TB
Ziehl Nielssen stain
True or false: incidence for CF in Caucasian people is 1 in 25
False
Describe the characteristics of adipose tissue
Loose connective tissue
Characteristic of conn tissue
Types: white and brown
Functions: energy, insulation, cushioning
Describe the characteristics of reticular tissue
?
Describe what the typical neuropathological hallmark of Parkinson’s disease
Lewy bodies found in the
What is prevalence
Usually expressed as a fraction, as a percentage or as number of cases per 10,000 or 100,000 people
Describe the difference between a sarcoma and carcinoma
?
Characteristics of a sarcoma
?
Characteristics of a blastoma
?
What is a hereditary risk factor for venous thrombosis
Factor 5 Leiden
When was the NHS cervical screening programme formally set up
1988
What is a benign tumour
A localised tissue of origin
State a pathology of connective tissue
Malignant melanoma, chondroma
What type of tissue is blood
Connective
What is the function of connective tissue
Cushioning and physical support
Where is transitional epithelia present
UT
Epithelial tissue is characterised by
Little extra cellular matrix (ECM)
Cirrhosis is defined as irreversible replacement of liver tissue by?
Collagen
What is caused by a mutation at the q31.2 locus of chromosome 7
Cystic fibrosis
True or false: pneumoconiosis is a Chronic Obstructive Pulmonary Disease
False
What is the optimal pH for lysosomal functioning
pH 4.5
What is the genetic inheritance pattern of MPS IIIA hurler
Autosomal recessive
Storage of heparan sulphate leads mainly to which phenotype in an MPS IIIB patient
Brain dysfunction
MPS I is caused by the lack of which enzyme?
a-L-Iduronidase
Which of the following surrounds each bundle of muscle fibres
Epimysium
Dychennes muscalar dystrophy is characterized by absence of which hormone
Dystropin
What are two infectious forms of dementia
Kuru
Frontotemporal dementia
Lewy bodies are a pathological hallmark of which disease
Parkinson’s
What are the most commonly used stains in non-gynaecology Cytology
Papanicolaou and giesma
Nepgrotic syndrome is characterised by?
Oliguria
True or false: immune complexes are a common feature ADPGN
False, compliment only
ADPGN is usually preceded by what
Streptococcal infection
Nephritic syndrome results from?
Disturbances in glomerular structure
The number oocytes (eggs) a woman has is referred to as her:
Ovarian Reserve
An audit following a sample through the laboratory is called
Sample audit
True or false: discussing he outcome of the audit is part of the clinical audit cycle
False
True or false: the HCPC promotes professional education and training
False: set standards of proficiency
How many layers does the ethical grid have
4
What is a vertical audit
A sample through a process from beginning to end
