Past Questions

Question 1

What dictiates the biological function of heparan sulphide?

Level and sulphation patterns of the way it’s attached to the core protein

Answer 1

Levels and sulphation pattern

Question 2

What is the key feature of hodgekins syndrome lymphoma as opposed to non-hodgekins

Answer 2

Presence of Reed-Sternberg cells (mature malignant B-lymphocytes) (multinucleated or bi-lobed)

Question 3

True or false: MPS 1 Hurlers is an autosomal dominant inherited disease

Answer 3

False: autosomal recessive

Question 4

What is aneuploidy

Answer 4

Abnormal amount of chromosomes

Question 5

In histology, how would you test for presence of acid-fast bacilli for TB

Answer 5

Ziehl Nielssen stain

Question 6

True or false: incidence for CF in Caucasian people is 1 in 25

Answer 6

False

Question 7

Describe the characteristics of adipose tissue

Answer 7

Loose connective tissue
Characteristic of conn tissue
Types: white and brown
Functions: energy, insulation, cushioning

Question 8

Describe the characteristics of reticular tissue

Answer 8

?

Question 9

Describe what the typical neuropathological hallmark of Parkinson’s disease

Answer 9

Lewy bodies found in the

Question 10

What is prevalence

Answer 10

Usually expressed as a fraction, as a percentage or as number of cases per 10,000 or 100,000 people

Question 11

Describe the difference between a sarcoma and carcinoma

Answer 11

?

Question 12

Characteristics of a sarcoma

Answer 12

?

Question 13

Characteristics of a blastoma

Answer 13

?

Question 14

What is a hereditary risk factor for venous thrombosis

Answer 14

Factor 5 Leiden

Question 15

When was the NHS cervical screening programme formally set up

Answer 15

1988

Question 16

What is a benign tumour

Answer 16

A localised tissue of origin

Question 17

State a pathology of connective tissue

Answer 17

Malignant melanoma, chondroma

Question 18

What type of tissue is blood

Answer 18

Connective

Question 19

What is the function of connective tissue

Answer 19

Cushioning and physical support

Question 20

Where is transitional epithelia present

Answer 20

UT

Question 21

Epithelial tissue is characterised by

Answer 21

Little extra cellular matrix (ECM)

Question 22

Cirrhosis is defined as irreversible replacement of liver tissue by?

Answer 22

Collagen

Question 23

What is caused by a mutation at the q31.2 locus of chromosome 7

Answer 23

Cystic fibrosis

Question 24

True or false: pneumoconiosis is a Chronic Obstructive Pulmonary Disease

Answer 24

False

Question 25

What is the optimal pH for lysosomal functioning

Answer 25

pH 4.5

Question 26

What is the genetic inheritance pattern of MPS IIIA hurler

Answer 26

Autosomal recessive

Question 27

Storage of heparan sulphate leads mainly to which phenotype in an MPS IIIB patient

Answer 27

Brain dysfunction

Question 28

MPS I is caused by the lack of which enzyme?

Answer 28

a-L-Iduronidase

Question 29

Which of the following surrounds each bundle of muscle fibres

Answer 29

Epimysium

Question 30

Dychennes muscalar dystrophy is characterized by absence of which hormone

Answer 30

Dystropin

Question 31

What are two infectious forms of dementia

Answer 31

Kuru | Frontotemporal dementia

Question 32

Lewy bodies are a pathological hallmark of which disease

Answer 32

Parkinson’s

Question 33

What are the most commonly used stains in non-gynaecology Cytology

Answer 33

Papanicolaou and giesma

Question 34

Nepgrotic syndrome is characterised by?

Answer 34

Oliguria

Question 35

True or false: immune complexes are a common feature ADPGN

Answer 35

False, compliment only

Question 36

ADPGN is usually preceded by what

Answer 36

Streptococcal infection

Question 37

Nephritic syndrome results from?

Answer 37

Disturbances in glomerular structure

Question 38

The number oocytes (eggs) a woman has is referred to as her:

Answer 38

Ovarian Reserve

Question 39

An audit following a sample through the laboratory is called

Answer 39

Sample audit

Question 40

True or false: discussing he outcome of the audit is part of the clinical audit cycle

Answer 40

False

Question 41

True or false: the HCPC promotes professional education and training

Answer 41

False: set standards of proficiency

Question 42

How many layers does the ethical grid have

Answer 42

4

Question 43

What is a vertical audit

Answer 43

A sample through a process from beginning to end