Passmedicine Flashcards
U waves seen on ECG
Hypokalaemia
J waves on ECG
Hypothermia
In hypokalaemia, you have no T, but a long PR and a long QT
And you are depressed
Hypokalaemia - small or absent T waves,
Long PR interval
Long QT
ST depression
Who should you avoid giving adenosine to?
Don’t give to asthmatics - could cause bronchospasm
Which drugs interact with adenosine?
DEAR
Dipyridamoles - Enhance effect
Aminophylline - Reduces effect
Adenosine adverse effects
Bronchospasm
Chest pain
Can enhance conduction down accessory pathways, resulting in increased ventricular rate (e.g. wolff parkinson white)
Most common cause of aortic stenosis in younger patients (<65)
Bicuspid aortic valve
Most common cause of aortic stenosis in older patients (>65)
Calcification of the aortic valve
What does a narrow pulse pressure indicate?
Decreased cardiac output
Which syndromes are associated with VSD?
Down’s syndrome
Patau syndrome
Edward’s syndrome
Fragile X is associated with, which heart problem?
Mitral valve prolapse
William’s syndrome is associated with which heart problem?
Supravavlular aortic stenosis
First line treatment for hypertension in a diabetic
ACE inhibitor
Investigation if you suspect a patient has aortic stenosis
Transthoracic echocardiogram
Which common drug, may cause skin necrosis (rare)
Warfarin
Patients are particularly at risk if they are given warfarin without LMWH, and it is most likely to occur in the first 3-5 days of treatment
1972 and protein C
Warfarin
Chest pain relieved when sitting forward
Pericarditis
ECG changes in pericarditis
Saddle shaped ST elevation
PR depression - most specific ECG marker for pericarditis
Acute management of SVT
Vagal manoeuvres
Adenosine 6mg-12mg-12mg (UNLESS ASTHMATIC - give verapamil instead)
Electrical cardioversion
Xanthomata are seen in what
Hyperlipidaemia
eruptive xanthomata - due to high triglyceride levels and present as multiple red/yellow vesicles on extensor surfaces
Does of adrenaline for baby - 6 years
150 micrograms, 0.15ml 1 in 1000
Does of adrenaline for 6 years to 12 years
300 micrograms, 0.3ml in 1 in 1000
Dose of adrenaline for adult and child >12 years
500 micrograms, 0.5ml 1 in 1000
Adverse effects of statins
Myopathy: includes myalgia, myositis, rhabdomyolysis and asymptomatic raised CK.
Risk factors for myopathy include advanced age, female sex, low BMI, presence of multisystem disease (e.g. diabetes)
ECG findings of Wolff parkinson white
Delta waves, short PR interval
Which drug are the most common cause of drug-induced angioedema
ACE inhibitors
ACE inhibitor mechanism of action
Inhibit conversion of angiotensin I to angiotensin II
Side effects of ACEis
Cough
Angioedema (may occur up to a year after starting treatment)
Hyperkalaemia
First-dose hypotension: more common in patients taking diuretics
Antagonists of the P2Y12 adenosine disphosphate receptor
Clopidogrel
Prasugrel
Statins interact with which drugs
Clarithromycin/erythromycin
The only shockable rhythms
Ventricular fibrillation and ventricular tachycardia
Where do thiazide diuretics work
Work at the beginning of the distal convoluted tubule (inhibit sodium reabsorption)
How long do thiazide diuretics take to work? And how long do they work for?
Begin to work after 1-2 hours, duration of action is 12-24 hours
Common adverse effects of thiazide diuretics
Dehydration Postural hypotension Hyponatremia, hypokalaemia, hypercalcemia Gout Impaired glucose tolerance Impotence
What QRISK should you offer statins for?
Offer if QRISK>10%
Side effects of GTN
Hypotension
Tachycardia
Headache
How does GTN work?
Causes release of nitric oxide in smooth muscle, increasing cGMP, which leads to a fall in intracellular calcium levels
Management of aortic stenosis
Valve replacement if the patient is symptomatic
If not, then only replace when aortic valve gradient >36mmHg
When might you want to measure BNP levels in patients?
Measure in patients who you think have heart failure, but no history of myocardial infarction
> 400 = poor prognosis
(If they have previous MI then they require urgent referral, echo and specialist assessment)
Describe BNP levels and heart failure
High levels = don’t confirm heart failure, but likely
Low levels = rule out heart failure
(Highly sensitive but varying specificity)
When might BNP levels be elevated?
In heart failure
But also LVH, myocardial ischaemia, atrial fibrillation, pulmonary hypertension, hypoxia, pulmonary embolism, right ventricular strain, COPD, liver failure, sepsis, diabetes and renal impairment,
May also be high in women, and particularly in people older than 70
What is BNP?
A hormone produced by left ventricular myocardium in response to strain
Antiplatelet regimen following stroke?
check ct first lol
300mg aspirin for 2 weeks then 75mg clopidogrel for life
Adrenaline dose for cardiac arrest
1mg
When do you give adrenaline in cardiac arrest?
Give after third shock, and then every 3-5 minutes (during alternate cycles of CPR)
Non-shockable rhythms
Pulseless electrical activity
Asystole
Initial treatment of PEA and asystole
Patients should immediately receive 1mg IV adrenaline and high quality CPR
Pericardial knock - loud S3
Constrictive pericarditis