Passmedicine Flashcards
1
Q
High-grade B-cell neoplasm, endemic in areas of Africa
A
Burkitt’s lymphoma
2
Q
Epidemiological factors in Burkitt’s lymphoma? (3)
A
Epstein-Barr virus (mainly endemic)
HIV patients
C-myc gene translocation t(8:14)
3
Q
Which areas are affected usually by a) endemic b) sporadic forms of Burkitt’s lymphoma?
A
a) maxilla or mandible
b) abdomen (ileocaecal)
4
Q
Microscopic hallmark of Burkitt’s lymphoma?
A
“Starry sky” appearance- sheets of lymphocytes interspersed with macrophages containing dead cells
5
Q
Complication of chemotherapy for Burkitt’s lymphoma?
A
Tumour lysis syndrome
