Lymphadenopathy and lymphoma

Question 1

Characteristics of lymphadenopathy suggesting lymphoma (4)

Answer 1

Non-tender
Rubbery/soft
Smooth
Superficial and non-tethered

Question 2

Symptoms of Hodgkins lymphoma (4)

Answer 2

Lymphadenopathy
Constitutional symptoms (e.g. fever night sweats, weight loss etc)
Alcohol induced lymph node pain
Mass effects of mediastinal nodes

Question 3

Cells with mirror-image nuclei found in Hodgkins lymphoma

Answer 3

Reed-Sternberg cells

Question 4

How are lymph node biopsies assessed?

Answer 4

Histology
Immunohistochemistry
Cytogenetic analysis
Molecular analysis

Question 5

Classification of lymphoma (3)

Answer 5

Hodgkins lymphoma
T-cell non-Hodgkins lymphoma
B-cell non-Hodgkins lymphoma

Question 6

What are lymphomas?

Answer 6

Malignant proliferations of lymphocytes accumulating in lymph nodes, but also in peripheral blood, organs

Question 7

Most common Hodgkins subtype

Answer 7

Nodular sclerosing

Question 8

Worst prognosis in Hodgkins

Answer 8

Lymphocyte depleted

Question 9

“B” symptoms of HL (3)

Answer 9

Weight loss >10% in last 6 months
Fever
Night sweats

Question 10

Treatment for Hodgkin’s lymphoma

Answer 10

Chemotherapy, radiotherapy or both

Question 11

Stage I HL

Answer 11

Single lymph node region

Question 12

Stage II HL

Answer 12

2 or more lymph nodes on same side of diaphragm

Question 13

Stage III HL

Answer 13

Involvement of nodes on both sides of the diaphragm

Question 14

Stage IV HL

Answer 14

Spread beyond lymph nodes e.g. bone marrow, liver