Iron Flashcards
1
Q
Typical plasma iron
A
4mg
2
Q
Two biggest stores of iron (other than in Hb)
A
Parenchymal tissue e.g. liver
Macrophages
3
Q
Serum ferritin is an indirect measure of…
A
storage iron
4
Q
% saturation of ferritin is a measure of…
A
iron supply
5
Q
Transporter of iron in duodenum
A
DMT-1
6
Q
Ferroportin
A
Facilitates iron export from enterocytes
7
Q
Hypocromic microcytic anaemias are caused by…
A
Deficient synthesis of haemoglobin
8
Q
Clinical features of hereditary haemochromatosis
A
Asymptomatic in early disease Weakness/fatigue Arthritis Cirrhosis Diabetes Cardiomyopathy
9
Q
Molecular cause of hereditary haemochromatosis
A
HFE mutations- autosomal recessive
10
Q
Treatment of hereditary haemochromatosis
A
Venesection weekly 450-500ml
11
Q
Reasons for iron-loading (5)
A
Repeated red cell transfusions Thalassaemia syndromes Sideroblastic anaemia Red cell aplasia Myelodysplasia
12
Q
Treatment of iron overload
A
iron-chelating agents
