Passmed - Haem Flashcards
x is the diagnostic investigation of choice is the investigation of choice for suspected Non-Hodgkin’s lymphoma
Excisional node biopsy
x 1st line imaging in suspected multiple myeloma
Whole body MRI
x is the mainstay of imaging for staging Hodgkin’s lymphoma
PET/СT
G6PD def. typical history + blood film?
Male (X-linked recessive)
- Neonatal jaundice
- Infection/drugs precipitate haemolysis
- Gallstones
- Heinz bodies
G6PD def. investigation?
Enzyme activity of G6PD
Hereditary spherocytosis typical history + blood film?
Male and female (autosomal dominant)
- Neonatal jaundice
- Chronic symptoms although haemolytic crises may be precipitated by infection
- Gallstones
- Splenomegaly is common
Spherocytes (round, lack of central pallor)
Hereditary spherocytosis investigation?
EMA binding test
‘CRAB’ features of multiple myeloma =
hyperCalcaemia, Renal failure, Anaemia (and thrombocytopenia) and Bone fractures/lytic lesions
grossly elevated APTT may be caused by
heparin therapy, haemophilia or antiphospholipid syndrome
Elevated APTT + normal factor VIIIc activity points to a diagnosis of
haemophilia B
Malaria prophylaxis (e.g. primaquine) can trigger haemolytic anaemia in those with x
G6PD deficiency
G6PD deficiency: x drugs can trigger haemolysis
sulph- drugs: sulphonamides, sulphasalazine and sulfonylureas
