Parvoviruses Flashcards
1
Q
Parvoviruses
Properties
A
– smallest virus, ssDNA, hairpin loops, nuclear, naked
2
Q
Parvoviruses
Gene products
A
Gene products – rep protein (NS1), VP1,2
3
Q
Parvoviruses
Replication
A
Replication – required DNA polymerase α or δ which is found during S phase of cell replication → damage to fetus
4
Q
Parvoviruses Sx
A
Sx – erythema infectiosum = Fifth disease (slapped cheek) in kids, joint pain and arthritis in adults, B19-Ab complexes
5
Q
Aplastic crisis
A
Aplastic crisis- viral replication in erythroid precursor cells, affects pts with pre-existing red cell disorders
6
Q
Hydrops fetalis
A
– crosses placental → killing of RBC precursors, CHF
7
Q
AAV
A
AAV – Adeno-associated parvovirus, require co-infection with Adeno or herpes, integrate into chromosome 19
