Parvoviridae

Question 1

Parvoviridae
Small (18-26 nM in diameter)
Envelope?
Morphology? 
Single-stranded RNA/DNA genome
No viral \_\_\_\_\_ encoded, requires host cell fx of late S or early G2 phase of cell cycle

Answer 1

Parvoviridae
Small (18-26 nM in diameter)
Envelope? NO
Morphology? ICOSAHEDRAL
Single-stranded DNA genome
No viral POLYMERASE encoded, requires host cell fx of late S or early G2 phase of cell cycle

Question 2

Target cells of Parvovirus

1) Stem cells in ____ ____ and _____ organs
2) Stem cells in crypts of _______
3) Cells in external granular layer of the _______
4) _______ cells

Answer 2

Target cells of Parvovirus

1) Stem cells in BONE MARROW and LYMPHOID organs
2) Stem cells in crypts of LIEBERKUHN
3) Cells in external granular layer of the CEREBELLUM
4) MYOCARDIAL cells

Question 3

NAME THE AGENT
Dz: hemorrhagic enteritis, myocarditis
Host: canidae, felidae, ursidae, procyonidae, mustelidae, viveridae
Transmission: fecal-oral, virus is durable in environment
Incubation period: 2-5 days

Answer 3

Canine Parvovirus-2

Question 4

Name the Agents (3)
Dz: Feline distemper, panleukopenia, feline enteritis, “cat fever”, feline ataxia
Host: felidae, some canids, procyonidae
Transmission: ingestion, contact, fomites, durable in environment,
Shed in feces, vomit, urine, saliva, prolonged shedding
Incubation: 2-10 days

Answer 4

Feline panleukopenia virus, Feline distemper virus, Feline parvovirus

Question 5

Neonatal Feline Parvovirus Infection Clinical Presentation:

1) In utero
a) ______ hypoplasia, ataxia, hypermetria
b) _______, circling
c) ________, retinal dysplasia, blindness
2) early gestatation: _______, _______

Answer 5

Neonatal Feline Parvovirus Infection Clinical Presentation:

1) In utero
a) CEREBELLAR hypoplasia, ataxia, hypermetria
b) HYDROCEPHALUS, circling
c) MICROPTHALMIA, retinal dysplasia, blindness
2) early gestatation: RESORPTION, ABORTION

Question 6

NAME THE AGENT
Dz:
1) Neonatal mink: acute, fatal interstitial pneumonia
2) Adults: persistent infection, chronic immune complex mediated dz
Host: mink, ferrets, skunks, raccoons

Answer 6

Aleutian Mink Disease Virus (ADMV)

Question 7

Porcine Parvovirus, ubiquitous, single serotype
Dz: _____, ______ fetuses, embryonic death and infertility (SMEDI)
Host:
Transmission: _____, ______, trans______ (10-14 days p.i.)
Shedding: _____, _____, other secretions

Answer 7

Porcine Parvovirus, ubiquitous, single serotype
Dz: STILLBIRTHS, MUMMIFIED fetuses, embryonic death and infertility (SMEDI)
Host:
Transmission: ORAL-NASAL, VENEREAL, transPLACENTAL (10-14 days p.i.)
Shedding: FECES, SEMEN, other secretions

Question 8

Clinical presentation of Porcine Parvovirus (PPV)

70 days=

Answer 8

Clinical presentation of Porcine Parvovirus (PPV)

70 days= WEAK PIGS, STUNTING, IMMUNE RESPONSE, CHRONIC/PROLONGED SHEDDING, POSSIBLE IMMUNOTOLERANCE

Question 9

Agent: CPV-1, genetically distinct from CPV-_
Dz: Interstitial pneumonia of _______ ______, mild enteritis, fetal _____, ________, resorption
Host range: ______, approx __% of adult ___ have abs to CPV-1

Answer 9

Agent: CPV-1, genetically distinct from CPV-2
Dz: Interstitial pneumonia of NEONATAL PUPPIES, mild enteritis, fetal DEATH, ABORTION, resorption
Host range: CANIDAE, approx 50% of adult DOGS have abs to CPV-1