Parvoviridae

Question 1

Human Strain of Parvovirus

Answer 1

B19

Question 2

Parvovirus Enveloped y/n?

Answer 2

No

Question 3

Parvovirus genome type

Answer 3

ssDNA, either + or -

Question 4

Parvovirus serotypes

Answer 4

Only one serotype

Question 5

Parvovirus B19 replicates in…

Answer 5

MITOTICALLY ACTIVE CELLS!

Question 6

Parvovirus prefers which cells?

Answer 6

Erythroid lineage cells

Question 7

Parvovirus binds to RBC ____ antigen

Answer 7

P antigen (globoside)

Question 8

Parvovirus is internalized to the cell via ____

Answer 8

encoded pits

Question 9

Parvovirus _______ genome is delivered to the nucleus where its converted to ________ by GROWING cells

Answer 9

ssDNA (+/-) converted to dsDNA

Question 10

Parvovirus assembly occurs in the _________

Answer 10

Nucleus

Question 11

Parvovirus is released by _______

Answer 11

cell lysis

Question 12

Parvovirus Clinical presentation (name)

Answer 12

5th disease/ Slapped-Cheek Disease

Question 13

Parvovirus incubation time

Answer 13

one week

Question 14

Parvovirus Phases

Answer 14

Early (contagious), Late phase (rash…three stages)

Question 15

Parvovirus late phase stages (3)

Answer 15

Rash on cheek……. Erythematous maculopapular rash on trunk and limbs……….. highly variable stage lasting 1-3 weeks

Question 16

Parvovirus in adults typically shows ____ involvement

Answer 16

joint (occurs in 80% of females)

Question 17

Pregnancy complication of Parvovirus

Answer 17

Hydrops fetalis

Question 18

Hydrops fetalis occurs because Parvovirus…

Answer 18

attacks reticulocytes which leads to anemia of the fetus and death

Question 19

Infection in the ___ trimester with Parvovirus is associated with a ____% fetal loss

Answer 19

1st = 5-10%………. 2nd = 12.5%

Question 20

Hydrops fetalis is diagnosed via ______

Answer 20

ultrasound

Question 21

Parvovirus anemia is a problem when patient develops _______. Who is at risk?

Answer 21

aplastic crisis. Patients with chronic hemolytic anemia or Sickle cell.

Question 22

Aplastic crisis can happen in what time frame?

Answer 22

7-10 days

Question 23

Parvovirus tramsmission

Answer 23

aersol, oral secretions, transplacental

Question 24

Parvovirus establishes ____ infection

Answer 24

lytic …. & large viremia

Question 25

Parvovirus causes ______ (type) of disease

Answer 25

biphasic: first from viremia (flu Sx and shedding)…. second from immune response (due to immune complexes in blood)

Question 26

Parvovirus seropositivity rates are ____ by 60 years old

Answer 26

90%

Question 27

Erythema infectiosum diagnosis is made via

Answer 27

clinical presentation

Question 28

Parvovirus definitive Dx made with…

Answer 28

Specific IgM + Detection of VIRAL DNA

Question 29

Parvovirus treatment

Answer 29

No Antiviral or vaccine