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Virology > Papillomaviridae & Polyomaviridae > Flashcards

Papillomaviridae & Polyomaviridae Flashcards

1
Q

Papillomavirus structure

A

dsDNA (Circular)

Nonenveloped

icosahedral capsid

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2
Q

Papillomavirus capsid proteins

A

L1 + L2

L1 = 80% of virion

L2 = Minor, makes up the rest

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3
Q

There are _____ types of Papillomavirus

A

100 types

*grouped into 16 groups (A-P)

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4
Q

Papillomavirus strains are classified as _____ or _____

A

high or low risk

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5
Q

Cervical cancer is consistent with HPV in _____% of cases

A

75%

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6
Q

Papillomavirus replication occurs in the _____ and assembly occurs in the ______

A

nucleus, nucleus

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7
Q

HPV replicates in ______ cells

A

differentiated skin cells

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8
Q

_____ genes stimulate HPV division and growth

A

Early genes

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9
Q

Based on TISSUE tropism, HPV’s are classified into _____ or ______

A

cutaneous or mucosal

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10
Q

Cutaneous HPV caused by strains…

A

1, 2, 3, 4

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11
Q

Cutaneous HPV incubation time

A

3-4 months

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12
Q

Mucosal HPV known to cause…

A

Single oral papillomas

Laryngeal papillomas

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13
Q

Most common benign epithelial tumors of the oral cavity are…

A

Single Oral Papillomas (Mucosal HPV)

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14
Q

Single oral papillomas features (2)

A

occur at any age

rarely recur

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15
Q

Laryngeal papillomas are associated with strains ______ and ____

A

6 + 11

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16
Q

Which mucosal papillomas are likelier to recur?

A

Laryngeal papillomas

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17
Q

A-G warts are caused by

A

condylomata acuminata

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18
Q

90% of AGW’s are associated with HPV___ and ____

A

6+11

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19
Q

HPV strains associated with infection of the female genital tract:

A

16, 18, 31, 45

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20
Q

85% of cervical carcinoma contains _______

A

integrated DNA from HPV

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21
Q

Explain oncogenesis in terms of cervical dysplasia and HPV

A

E6 +E7 are oncogenic, and normally inhibited by E1+E2

E2 is broken to promote DNA integration

6 + 7 are free to bind p53 + RB genes and INHIBIT them

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22
Q

Cells of the ________________ are invaded by HPV

A

basal layer of epidermis

23
Q

HPV infections can result in two outcomes - what are they?

A

Latent or Lytic

24
Q

Latent HPV phase can have ______ and last for ______

A

no Sx

Last from Months to Years

25
Q

After HPV latency, what begins?

A

Production of :

  • DNA
  • Capsid
  • Particles
26
Q

Expression of structural proteins and vegetative DNA synthesis is limited to

A

terminally differentiated epidermal cells

27
Q

Morphologic changes of host cells from HPV infection is called ______

A

Koilocytosis

28
Q

HPV viremia lasts how long?

A

HPV does NOT cause viremia!!

29
Q

HPV proteins for virus assembly and release

A

L1, L2, E4

30
Q

HPV proteins for cell proliferation and replication?

A

E1 - E7 (*but not E3)

31
Q

Koilocyte appearance

A

Multinucleated,

Big, hyperchromatic nucleus with irregular outlines

Perinuclear halo

32
Q

HPV transmitted on _____

A

fomites

33
Q

______ may promote HPV transmission

A

asymptomatic shedding

34
Q

Lab tests for HPV can detect ___, ___, or ____

A

virus Nucleic Acid

Viral Antigens

Koiloctyotic cells

35
Q

HPV control

A
  • Podophyllin resin, podofilox lotion
  • Aldara cream (= immune response modifier, stimulate cytokines and interferon)
  • VACCINE
36
Q

HPV vaccines

A

Gardasil and Cervarix

37
Q

Gardasil contains recombinant ____________

A

VLP’s of 6, 11, 16, 18

38
Q

Guardasil protects against ____ strains of HPV, which cause 70% of Cervical neoplasias worldwide

A

16 + 18

39
Q

Gardasil mechanism

A

Triggers antibody response that prevents infection from the included types

40
Q

Gardasil dosing schedule

A

given in 3 doses

0, 2, 6 months

41
Q

Polyomaviruses (viruses)

A

BK + JC

(SV40 [simian] and murine)

42
Q

Polyomaviruses differences from papillomaviruses

A

smaller and less complex

replicate in:

  • Resp
  • urinary
  • CNS (JC only)
43
Q

Polyomaviruses are activated in _______ patients

A

immunocompromised

(also pregnant patients, but no transmission to the fetus)

44
Q

Two infections caused by BK virus:

A
  1. Ureteral stenosis (renal transplant pts)
  2. Hemorrhagic cystits (bone marrow transplant pts)
45
Q

Main JC virus infection

A

Progressive Multifocal Leukoencephalopathy (PML)

*occurs in IC patients (e.g. AIDS)

46
Q

JC virus infects _____ cells, which results in ….

A

Oligodendrocytes

multifocal demyelination of CNS

47
Q

PML prognosis

A

1-4 months

48
Q

Polyomaviruses are limited to _______ and _______

A

specific hosts + cell types

49
Q

JC+BK enter the ________ and infect ________

Then enter the _______ with minimal effect

A

respiratory tract

lymphocytes

kidney

50
Q

BK virus establishes _______ in kidney

A

latent infection

51
Q

JC cirus establishes infection where?

A

kidneys, B cells, monocyte-lineage cells

52
Q

After multiplication in the kidney, JC/BK cause ____________ , which either results in permanent latent kidney infection (in non-IC) or reactivation and progression (in IC pts).

A

causes transient secondary viremia

53
Q

BK more likely to cause _____ infections,

JC may cause _____ infection

A

BK –> UTI

JC –> CNS

54
Q

Polyomaviruses control/treatment

A

None

Virology (13 decks)

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