part 4

Question 1

• Inhibits COX 1 and 2
• used to treat inflammatory disorders (rheumatoid arthritis, osteoarthritis, bursitis)
• alleviates mild to moderate pain
• suppresses fever
• relieves dysmenorrhea
• suppresses inflammation but pose risk of serious harm

Answer 1

First-Generation NSAIDs

Question 2

Nonselective inhibitor of cyclooxyrgenase

Answer 2

Aspirin (ASA)

Question 3

What are the therapeutic uses of Aspirin (ASA)?

Answer 3

analgesic
antipyretic
anti-inflammatory
inhibits COX 2
suppresses platelet aggregation 
protects in thrombotic disorders (MI and stroke) 
dysmenorrhea (cramps) 
cancer prevention (colorectal) 
prevention of alzheimers disease

Question 4

What are the AE’s of aspirin?

Answer 4

• GI problems: heartburn and nausea
• bleeding
• renal impairment
• salicylism: tinnitus (ringing in the ears), sweating, headache, and dizziness
• Reye’s syndrome (swelling in the brain)
• hypersensitivity reaction
• dont use if pregnant

Question 5

What are the drug interactions of Aspirin?

Answer 5

• anticoagulants: warfarin and heparin
• glucocorticoids
• alcohol
• ibuprofen
• ace inhibits and ARBs

Question 6

What are the S/S of acute aspirin poisoning?

Answer 6

life threatening

• respiratory depression
• hyperthermia
• dehydration
• acidosis
• treatment is supportive

Question 7

What are non aspirin first gen NSAIDs?

Answer 7

• aspirin like with fewer GI, renal, and hemorrhagic effects
• 20+ non aspirin NSAIDs available (some patients do better on one than another)
• they inhibit COX 1 and 2 and inhibition is reversible (unlike aspirin)

Question 8

What are the principle indications for first gen non aspirin NSAIDs?

Answer 8

rheumatoid arthritis and osteoarthritis

Question 9

Do non aspirin NSAIds protect against MI and stroke?

Answer 9

NO

Question 10

What are the first generation non aspirin NSAIDs?

Answer 10

-Ibuprofen (advil and motrin)