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IDIT > Parsa > Flashcards

Parsa Flashcards

1
Q

karyolysis

A

basophilia fades

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2
Q

pyknosis

A

nuclear shrinkage, increased basophilia

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3
Q

karyorrhexis

A

nuclear fragmentation

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4
Q

coagulative necrosis

A

ischemia of solid organs

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5
Q

hemorrhagic necrosis

A

venous vessel obstructed or artery plugged in softer tissue

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6
Q

liquefactive necrosis

A

abscess filled with enzymes or neutrophils create pus

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7
Q

gangrenous necrosis

A

blockage of blood vessels in leg

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8
Q

caseous necrosis

A

tuberculosis

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9
Q

gumma necrosis

A

syphilis

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10
Q

enzymatic fat necrosis

A

acute pancreatitis

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11
Q

fibrinoid necrosis

A

immune complex deposition in vascular walls

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12
Q

mercury chemical injury

A

binds cell membrane proteins to increase permeability (direct)

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13
Q

cyanide chemical injury

A

inhibits mitochondrial oxidative phosphorylation (direct)

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14
Q

CCl4

A

creates free radical *CCl3 (toxic metabolite)

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15
Q

acetaminophen

A

creates NAPQI (toxic metabolite)

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16
Q

fatty change in liver

A

normal endogenous substance produced excessively or removed inadequately

17
Q

lysosomal storage disease

A

defects in metabolic enzymes lead to accumulation of normal endogenous substance

18
Q

silicosis

A

cell can’t degrade or transport abnormal endogenous substance

19
Q

a1-antitrypsin in liver

A

defects in protein folding and degradation lead to accumulation of abnormal endogenous substance

20
Q

fatty liver causes

A

alcoholism, diabetes, obesity, starvation

21
Q

proteinuria

A

protein leakage across glomerulus, increased reabsorption of protein into vesicles (hyaline droplets)

22
Q

diabetic liver

A

glycogen accumulates

23
Q

dystrophic calcification

A

occurs locally in dying tissues

24
Q

metastatic calcification

A

hypercalcemia (disturbance in calcium metabolism)

25
Q

hypertrophy/hyperplasia causes

A

increased demand/stimulation (growth factors, hormones)

26
Q

atrophy causes

A

decreased demand/stimulation

27
Q

metaplasia causes

A

chronic irritation (physical/chemical)

28
Q

reversible injury effects

A

cellular swelling, fatty change

29
Q

irreversible injury (cell death) effects

A

necrosis, apoptosis

30
Q

cellular aging causes

A

cumulative sublethal injury over a long lifespan

IDIT (7 decks)

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