Parkinsons

Question 1

Parkinsons is a

Answer 1

progressive loss of dopaminergic neurons = dopamine deficiency = lack of body movement control

Question 2

PD symptoms motor vs non-motor

Answer 2

motor
~ hypokinesia
~ bradykinesia
~ rigidity
~ rest tremor
~ postural instability

non-motor
~ dementia
~ depression
~ sleep disturbances
~ speech/language changes
~ swallowing
~ weight loss

Question 3

PD tx withdrawal info

Answer 3

NEVER ABRUPTLY WITHDRAW
~ can cause acute akinesia , neuroleptic malignant syndrome

Question 4

Dopaminergic drugs classes

Answer 4

~ Levodopa (dopamine precursor)
~ Dopamine receptor agonists (mimic dopamine action)
~ MAO-B inhibitors
~ COMT inhibitors

Question 5

dopamine receptor agonists