Parkinsons Flashcards
True or false
Dopamine crosses the BBB
False
True or false
Tolcapone (COMT inhibitors) crosses the BBB
True
True or false
Carbidopa crosses the BBB
False
What are drugs that decrease metabolism of levodopa
AADC inhibitors : carbidopa
COMT inhibitors :tolcapone
Examples of MAO-B inhibitors
Selegiline (selective)
Rasagiline (non selective)
Give 2 pharmacologic actions of amantadine
Ca channel blocker
Dopamine reuptake inhibitor
Dopamine reuptake inhibitor used in Tx of parkinsons disease
Amantadine
1st line tx in a parkinsons disease pt with mild severity and no cognitive impairment
MAO B inhibitor
1st line tx in a parkinsons disease pt with mild/moderate severity and no cognitive impairment
Dopamine agonist
1st line 5x in a parkinsons disease pt with mod./severe disability aged >70 yrs with cognitive impairment
Begin levodopa