Parkinsons Flashcards

1
Q

True or false
Dopamine crosses the BBB

A

False

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2
Q

True or false
Tolcapone (COMT inhibitors) crosses the BBB

A

True

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3
Q

True or false
Carbidopa crosses the BBB

A

False

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4
Q

What are drugs that decrease metabolism of levodopa

A

AADC inhibitors : carbidopa
COMT inhibitors :tolcapone

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5
Q

Examples of MAO-B inhibitors

A

Selegiline (selective)
Rasagiline (non selective)

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6
Q

Give 2 pharmacologic actions of amantadine

A

Ca channel blocker
Dopamine reuptake inhibitor

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7
Q

Dopamine reuptake inhibitor used in Tx of parkinsons disease

A

Amantadine

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8
Q

1st line tx in a parkinsons disease pt with mild severity and no cognitive impairment

A

MAO B inhibitor

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9
Q

1st line tx in a parkinsons disease pt with mild/moderate severity and no cognitive impairment

A

Dopamine agonist

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10
Q

1st line 5x in a parkinsons disease pt with mod./severe disability aged >70 yrs with cognitive impairment

A

Begin levodopa

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