Parkinson's Disease

Question 1

What is Parkinson’s Disease due to?

Answer 1

Due to lack of dopaminergic neurones in substantia nigra

Question 2

What is the Parkinson’s Triad?

Answer 2

1. Rigidity
2. Bradykinesia
3. Tremor

Question 3

What are the 6 Ms of Parkinson’s?

Answer 3

1. Monotonous
2. Micrographia
3. HypoMimesis
4. March a petit pas (shuffling)
5. Misery (depression)
6. Memory loss

Question 4

What is Drug-induced Parkinson’s?

Answer 4

Due to drugs that lower dopamine

Question 5

What drugs lower dopamine?

Answer 5

Like antiemetics (metoclopramide) antipsychotics

Question 6

How is Parkinson’s Disease Dementia diagnosed?

Answer 6

With an established diagnosis of Parkinson’s and then cognitive impairment.

Question 7

What are the symptoms of PDD?

Answer 7

1. Motor symptoms —-> Cognitive impairment
2. Hallucinations (when on treatment)
3. Delusions
4. Daytime sleepiness
5. Apathy

Question 8

What is the difference with PDD and Lewy Body Dementia?

Answer 8

PDD: A longer period of time (4-5 years) between the onset of motor symptoms and cognitive dementia.
LBD: Develops within a year of motor symptom onset and can be diagnosed without motor symptoms.