Parkinson's and Alzheimers Flashcards
Parkinson’s Disease
degenerative neuro disease, 2nd most common, onset is 50-60, men > women, permanent loss of dopamine producing nerve cells
Parkinsons patho
degenerative disorder of substantia nigra, a basal ganglia structure in mid brain, responsible for movement
Cells degenerate»_space;>
Results in depletion of dopamine (inhibitory neurotransmitter) &
increase in acetylcholine (excitatory neurotransmitter)
Causes impairment of movement
Parkinsons symptoms
Debilitating disease
4 cardinal signs
T.R.A.P.
1. Tremor
…often the 1st sign
2. Rigidity of muscles
3. Akinesia
loss of ability to move muscles
…or bradykinesia (slow movement)
4. Postural instability
40% of parkinson’s patients have what cognitive impairment?
Dementia
Other symptoms of Parkinsons
emotional lability, depression, paranoia, rapid mood swings, sleep disturbances, pill rolling tremor
Parkinson’s etiology
unknown, fungicides, well water consumption, genetic, head trauma (boxing)
Parkinson’s diagnostics
no specific diagnostic, SPECT scan, MRI, CT, Labs, made primarily by symptoms
SPECT
single photon emission tomography, to detect how brain produces/ uses dopamine
Parkinson’s Nursing care
Ineffective airway clearance, potential for injury, alteration in mobility, alteration in communication (slides 13-15)
Parkinson’s meds
Sinemet- levodopa carbidopa (levodopa converts to dopamine, carbidopa prevents reuptake)
Sinemet adverse effects
watch for hypotension
headache, N/V, loss of appetite, insomnia, unusual dreams
uncontrolled repetitive movements of tongue, lips, face, arms, legs
Tardive Dyskinesia
Sinemet toxicity
increased confusion, increased rigidity, hallucinations
Drug holiday for Sinemet
reduce medication dosage
change in medications
careful monitoring of patients during this time
because of potential complications: swallowing, injury etc….
Alzheimer’s
form of dementia (60-80%), degenerative disease of the brain, progressive impairment, no known cause or cure, eventually fatal
Facts about Alzheimer’s
Primarily affects > 65
Early onset
can begin at age 40-50
Fastest growing age-group in U.S.
>85 years
Likelihood of developing Alzheimer’s
doubles every 5 years after age 65
Affects > 5 million Americans
Almost 2/3 = women
6th leading cause of death
1 in 3 seniors die w/ Alzheimer’s dementia
Women 2x more likely to develop Alzheimer’s
than breast cancer
By 2050, may affect an estimated 16 million
people