Parkinson's and Alzheimers Flashcards

1
Q

Parkinson’s Disease

A

degenerative neuro disease, 2nd most common, onset is 50-60, men > women, permanent loss of dopamine producing nerve cells

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2
Q

Parkinsons patho

A

degenerative disorder of substantia nigra, a basal ganglia structure in mid brain, responsible for movement

Cells degenerate&raquo_space;>
 Results in depletion of dopamine (inhibitory neurotransmitter) &
increase in acetylcholine (excitatory neurotransmitter)
 Causes impairment of movement

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3
Q

Parkinsons symptoms

A

Debilitating disease
4 cardinal signs
T.R.A.P.
 1. Tremor
…often the 1st sign
 2. Rigidity of muscles
 3. Akinesia
loss of ability to move muscles
…or bradykinesia (slow movement)
 4. Postural instability

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4
Q

40% of parkinson’s patients have what cognitive impairment?

A

Dementia

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5
Q

Other symptoms of Parkinsons

A

emotional lability, depression, paranoia, rapid mood swings, sleep disturbances, pill rolling tremor

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6
Q

Parkinson’s etiology

A

unknown, fungicides, well water consumption, genetic, head trauma (boxing)

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7
Q

Parkinson’s diagnostics

A

no specific diagnostic, SPECT scan, MRI, CT, Labs, made primarily by symptoms

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8
Q

SPECT

A

single photon emission tomography, to detect how brain produces/ uses dopamine

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9
Q

Parkinson’s Nursing care

A

Ineffective airway clearance, potential for injury, alteration in mobility, alteration in communication (slides 13-15)

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10
Q

Parkinson’s meds

A

Sinemet- levodopa carbidopa (levodopa converts to dopamine, carbidopa prevents reuptake)

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11
Q

Sinemet adverse effects

A

watch for hypotension
 headache, N/V, loss of appetite, insomnia, unusual dreams
 uncontrolled repetitive movements of tongue, lips, face, arms, legs
Tardive Dyskinesia

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12
Q

Sinemet toxicity

A

increased confusion, increased rigidity, hallucinations

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13
Q

Drug holiday for Sinemet

A

reduce medication dosage
 change in medications
 careful monitoring of patients during this time
 because of potential complications: swallowing, injury etc….

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14
Q

Alzheimer’s

A

form of dementia (60-80%), degenerative disease of the brain, progressive impairment, no known cause or cure, eventually fatal

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15
Q

Facts about Alzheimer’s

A

 Primarily affects > 65
 Early onset
 can begin at age 40-50
 Fastest growing age-group in U.S.
 >85 years
 Likelihood of developing Alzheimer’s
 doubles every 5 years after age 65
 Affects > 5 million Americans
 Almost 2/3 = women
 6th leading cause of death
 1 in 3 seniors die w/ Alzheimer’s dementia
 Women 2x more likely to develop Alzheimer’s
than breast cancer
 By 2050, may affect an estimated 16 million
people

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16
Q

Fatality of Alzheimer’s disease

A

end stages- impacts balance, walking and swallowing
cause of death- complications of immobility (falls, pneumonia, UTIs, pressure sores, aspiration)

17
Q

Alzheimer’s patho

A

Plaques
 Excess deposits of beta amyloid protein
 normal amounts help neurons to grow
 Protein fragments clump into plaques
 and impair function of neurons
Tangles
 Threads of special protein (Tau) become tangled
 this affects neuron transport system
 Production of neurotransmitters decreased
 chemical “messenger” between neurons & cells
 Serotonin
 Acetylcholine

18
Q

Alzheimer’s causes

A

Genetic Factors
 Chromosomal abnormalities
 Alteration in chromosome
 1, 14, 19, 21
Environmental Factors
 Free radicals
 build up in neurons
 can lead to oxidative damage
 Aluminum & mercury
 environmental toxins

19
Q

Alzheimer’s risk factors

A

 Age
 Lack of exercise
 Depression
 CKD
 Obesity
 Exposure to metals/toxins
 Previous head injury

20
Q

Alzheimer’s S&S

A

 Forgetfulness
 Recent memory loss
 Difficulty learning & remembering
 Inability to concentrate
 Decline in personal hygiene & appearance
 Decline in inhibitions
 Difficulty communicating
Symptoms are staged on a scale of 1-7

21
Q

What are the 10 warning signs of AD

A

 1. Memory loss
 2. Challenges in planning/solving
 3. Difficulty completing familiar tasks
 4. Confusion w/ time and place
 5. Trouble understanding images
 6. New problems with speaking/writing
 7. Misplacing things
 8. Decreased/poor judgment
 9. Withdrawal from work/social activities
 10. Changes in mood/personality

22
Q

Alzheimer’s diagnosis

A

 Detailed medical & family history
 Physical exam
 neurologic and functional assessment
 MRI
 to rule out pathologic lesions
 PET scan
 Genotyping
 process of examining DNA
 to confirm diagnosis of late-onset AD

23
Q

Early to moderate stage meds

A

Cholinesterase inhibitors: prevent breakdown of
acetylcholine (ACH) = chemical messenger for learning
& memory
 donepezil (Aricept)
 rivastigmine (Excelon)
 galantamine (Razadyne)
 Side effects: N/V, loss of appetite, increased
frequency of BM’s

24
Q

Moderate to severe meds

A

NMDA receptor blocker: Glutamate (a neurotransmitter)
is blocked
 Increased levels of glutamate can lead to brain cell death
 memantine (Namenda)
 Usually in combination with cholinesterase inhibitor
 Can delay progression of symptoms
 Side effects: HA, constipation, dizziness

25
Q

Vitamin E and Alzheimer’s

A

 Antioxidant: may protect brain cells
 1997, Alzheimer’s Disease Cooperative Study
 High doses delayed loss of ability to carry out ADL’s
 ongoing research
 does it help or hinder ??
 NOT an FDA approved treatment
 must be prescribed…may interact w/ other meds
 studies have shown high dose vitamin E linked with
increased death risk in patients with CV disease

26
Q

Do Alzheimer’s meds provide a cure?

A

No (implications: slide 23)

27
Q

Alternative treatments for Alzheimer’s

A

 Fish & omega-3 polyunsaturated fats
 Decreases blood levels of beta amyloid protein
 ongoing research
 Antioxidants
 Cocktail of vitamin E, vitamin C, & alpha lipoic
acid
 Coenzyme-Q10
 Mediterranean diet
 Curcumin (curry spice)
 Wine – moderate consumption ??
 Limited evidence
 Puzzle games, memory games, using non-dominant
hand, writing
 Pet therapy
 Decreases anxiety,
increases communication,
improve mood,
increase comfort,
decreases BP

28
Q

Alzheimer’s Research

A

 Vaccine Development
 Clinical trials
 Increase active immune defense against beta amyloid
 Estrogen Therapy
 May enhance cognitive function in postmenopausal women
 conflicting research results
 Immunotherapy
 clearing neurotoxic beta amyloid from brain using passive
immunization

29
Q

Alzheimer’s nursing care

A

 Ensuring patient safety
 Providing physical care
 Promoting therapy and activity
 Respecting the individual
 Supporting the patients family