Parkinson Disease Drugs Flashcards
Levodopa, COMT inhibitors, Dopamine agonists, MAO-B inhibitors, Anticholinergics, and Amantadine are all drugs used to treat _____ disease
Parkinsons
Selegilline and Rasagilline are both ______ ______
MAO-B Inhibitors
Trihexyphenidyl, Benztropine mesylate, biperiden, orphenadrine, and Procyclidine are all Centrally acting _____ ______
Anti-Muscarinics
Unlike dopamine, the therapeutic drug ____, crosses the BBB
Levodopa
3 Non-Ergot Dopamine Agonist drugs
- Ropinirole (D2+)
- Pramipexole (D3+)
- Rotigotine
Similar to tolcapone, _____ blocks COMT, but only in the periphery
Entacapone
A _____ tremor is found in Parkinsons
Resting
Tolcapone inhibits the enzyme ______, which prevents the metabolism of Dopamine into 3-OMD in BOTH central and peripheral
COMT
A high protein meal will ____ absorption of Levodopa
Delay
2 drugs that metabolize Levodopa in peripheral tissues
- L-AAD
2. COMT
3 Medical conditions that Contraindicate Levodopa
- Psychosis
- Glaucoma (Angle-closure , Acute)
- Peptic Ulcers
In peripheral tissues, L-Aromatic Amino acid decarboxylase (L-AAD) and Catechol-O-methyltransferase (COMT) will transform Levodopa. The main decarboxylase inhbiitor used to bypass the peripheral transormation is ______
Carbidopa
Ropinirole, which is metabolized by _____ and Pramipexole, which is excreted unchanged in urine, are both ______ Derivatives used to treat Parkinsons via Dopamine ______
- CYP1A2
- Non-Ergot
- Agonisms
Plasma Half-life of Levodopa is ____ to _____ hours
1-3
Studies suggest that Rasagiline and Selegiline might have a ______M effect, by preventing the buildup of _______
- Neuroprotective
- Free-radicals
