Cholinergics

Question 1

_____ Acetylcholine receptors are ligand-gated ion channels; found either on endplate receptors for muscles or ganglion receptors for neurons

Answer 1

Nicotinic

Question 2

_____ Acetylcholine receptors are metabotropic G-protein coupled receptors

Answer 2

Muscarinic

Question 3

M1, M3, and M5 muscarinic receptors all use the _____ –> _____ –> ______ pathway

Answer 3

• IP3
• DAG
• Intracellular Calcium

Question 4

Varenicline and Succinylcholine are both _____ Cholinoceptor Agonists

Answer 4

Nicotinic

Question 5

Bethanechol and Pilocarpine are both _____ Cholinoceptor Agonists

Answer 5

Muscarinic

Question 6

Ganglion blockers and neuromuscular blockers are both _____ Antagonists

Answer 6

Nicotinic

Question 7

Tropines, Amines, and Amides are all _____ Antagonists

Answer 7

Muscarinic

Question 8

Hemicholiniums and Vesamicol both interfere with Ach’s ____ ____ or ___ __ _____

Answer 8

• Precursor uptake

- Entry to Vesicles

Question 9

Botulinum Toxin interferes with ______s and ______s to block vesicular fusion

Answer 9

• VAMP

- SNAP

Question 10

To break down Ach, _______ uses its Serine to bind to the Aceytl group and hydroylzes it

Answer 10

Acetylcholinesterase

Question 11

Edrophonium binds weakly and reversible to the anionic domain of _____, to boos the product of ACh

Answer 11

AChEsterase

Question 12

An intermediate-acting AChE inhibitor such as Neostigmine’s duration of action is determined by the stability of the ________ complex, not by plasma half-life

Answer 12

Enzyme-Inhibitor

Question 13

Neostigmine, Pyridostigmine,Physostigmine, Ambenonium, and demecarium all inhibit _______

Answer 13

Acetylcholinesterase

Question 14

Physostigmine crosses the BBB, but is only used _____ to treat Glaucoma

Answer 14

Topically

Question 15

Organophosphate insecticides and Chemical warfare agents kill you by inhibiting _____

Answer 15

Acetylcholinesterase

Question 16

Muscarinic vs Nicotininc Cholinergic Excess presenation

Answer 16

• Musc gives usual Sweat, lacrimal, Vasodilation, dilated pupils
• Nicotinic Gives convulsions and paralysis

Question 17

Pralidoxime has an Oxime group that is used for:

Answer 17

Treatment of AChE inhibition causing Ach overload