Local Anesthetics

Question 1

What happens to motor and sensory in Transient Neurologic Symtpoms (TNS)

Answer 1

nothing

Question 2

Although the Neuraxial Blockade for anesthesia is intuitive, the PERIPHERAL blockade first loses _____ fibers, then _____ fibers, and lastly _____ fibers

Answer 2

• Motor
• Proximal Sensory
• Distal Sensory

Question 3

Rpivacaine is similar to Bupivacaine, but with less _____

Answer 3

Cardiotoxicity

Question 4

Bupivacaine is an excellent long duration LA with a devastating potential for ____ ____

Answer 4

Cardiac

Question 5

Tetracaine lasts a long time and is used primarly for _____ anesthesia it’s toxic at low doses.

Answer 5

Spinal

Question 6

Eutectic Mixture of Local Anesthetic consists of ____ and _____ and is used TOPICALLY

Answer 6

Prilocaine and Lidocaine

Question 7

Benzocaine is primarliy used as a ______ and has MetHb potential

Answer 7

Topical

Question 8

When local anesthetics are ______ they can diffuse through the cell

Answer 8

Uncharged

Question 9

Cocaine, Tetracaine, Benzocaine, Procaine, and Chloroprocaine are all ____ based anesthetics

Answer 9

Ester

Question 10

Greater lipophilicity in local anesthetics results in a ______ onset

Answer 10

Slower

Question 11

Chloroprocaine used to have a bad rep, but now it’s a _____ onset and ____ duration Local anesthetic

Answer 11

• Quick

- Long

Question 12

When local anesthetics are ____ they are trapped within the cell and activate the receptor

Answer 12

Charged

Question 13

Ester local anesthetics are processed by

Answer 13

Esterases

Question 14

Mepivacaine lasts _____ than lidocaine and is the LOWEST pKa, most acidic, and acts a vasoconstricter

Answer 14

Longer

Question 15

Prilocaine is bad b/c it’s associated with ______

Answer 15

Methemoglobinemia

Question 16

Methemoglobinema is treated by methylene blue, two key findings are :

Answer 16

1. Chocolate Colored blood

2. 85% pluse ox

Question 17

Amide local anesthetics are processed by

Answer 17

CYP450 enzymes

Question 18

Lido, Mepi, Prilo, Bupi, and ROPI are all _____ based anesthetics

Answer 18

Amide

Question 19

Lidocaine is ideal because it’s a ____ onset, with ____ duration, and low toxicity

Answer 19

• Quick

- Moderate

Question 20

Although Procaine (Novocaine) has a quick onset and short duration, it unfortunately has a lot of ______ ______, and so it is rarely used now.

Answer 20

Hypersensitivity reactions