Parenteral products II Flashcards

1
Q

materials used for parenteral products

A

-containers
-syringes
-needles

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2
Q

Containers

A

-direct contact w product
-considered “ingredients”
-glass most commonly used
-type I, II, III glass
-use type I

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3
Q

Vials

A

-glass or plastic
-flip off cap protects the rubber stopper
-wipe to make sure it is sterile when first exposed

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4
Q

Ampuls

A

-glass
-single use
-hermetic, uniform containment
-head,neck,shoulder,body

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5
Q

IV bags

A

-large volume container
-gravity set
-piggyback container

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6
Q

Drop conversion factor

A

Drop Number

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7
Q

Syringes

A

-leur tip
-Luer Lok for hazardous drugs

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8
Q

Syringe measuring

A

-use final edge of plunger to read volume
-accuracy 1/2 of smallest division

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9
Q

Needles

A

-sterile over-wrap packaging
-sized by gauge and length
-filter needs must be used with ampuls

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10
Q

Gauge

A

-diameter of bore

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11
Q

filter needles

A

must be used when using ampules

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12
Q

Why is IV least forgiving?

A

-immediate distribution
-skip line of defense

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13
Q

Methods of IV admin

A

-bolus (push)
-infusion

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14
Q

Site of IV admin

A

-peripheral vein
-central vein

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15
Q

infusion mode of IV admin

A

-continuous admin
-intermittent admin

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16
Q

IV route is characterized by

A

rapid onset of action bc no absorption step

17
Q

Bolus dose graph

18
Q

infusion graph

A

-plataeu then decline

19
Q

common venous complications

A

-phlebitis
-thrombosis
-thrombophlebitis

20
Q

Phlebitis

A

-inflammation from irritation of the tunica intima of the vein
-mod to severe discomfort
-days to months to subside
-limits veins available for future therapy

21
Q

Thrombosis

A

-blood clot in vein
-pain
-swelling
-pulmonary embolism

22
Q

Set up for continuous IV infusion

A

-solution container
-spike
-drip chamber
-roll clamp
-tubing
-needle adapter

23
Q

Set up for intermittent IV infusion

A

-piggyback container
-Y injection site
-large volume container
-roll clamp
-one-way check valve
-needle adapter

24
Q

Central Vein IV infusion

A

-subclavian vein to superior vena cava

25
Sites of IM admin
-deltoid (2mL) -thigh (5mL) -gluteal (5mL)
26
IM mode of action
-has an absorption step -not always faster than oral route
27
SC sadmin
-similar to IM -slower absorption due to lower vascularization -volume < 1.5 mL
28
Hypodermoclysis
-infusion by SC route
29
Routes of admin graph
slide 26
30
Intra-spinal admin
-intrathecal -epidural
31
Intrathecal
-into subarachnoid space and CSF
32
epidural
-into space at thoracic or lumbar level between dura mater and vetebral canal (epidural space)
33
Intrathecal admin
-bolus -directly into CSF (no membrane to cross) -continuous admin not recommended -higher potency than epidural
34
What is First Air
USP 797 google it
35
Epidural admin
-bolus or continuous -in neonates at caudal level -near tip of tailbone into small opening
36
take special care with intra spinal!!
-must be isotonic -physiological pH -NO preservatives -even gauge can matter
37
In general, if an injectible excipient is tolerated by IV route it will be tolerated by
-IM and SC routes -not always tho (citrates!)
38
Parenterals
-IV -IM -SC -Intra-spinal
39
Absorption of parenterals
-IV: none -IM and SC: yes -bypass first-pass metabolism