23: Nanomedicine Flashcards
Nanoparticulate drug carriers
-micelles
-liposomes
-protein nanoparticles
Micelles
-surfactant molecule aggregates in aq solution at certain concentration and temp
-block co-polymers
surfactant
-polar head
-nonpolar tail
Micelles mech of blocking co-polymers
-hydrophilic or hydrophobic polymer block
Taxol
-Paclitaxel and Cremophor in 1 ml 50% dehydrated alcohol
Taxol use
-1st line for advanced ovary carcinoma
-adj treatment of nose-positive breast cancer
-1st line for non-small cell lung cancer
-2nd line for AIDs relate Kaposi sarcoma
Paclitaxel
-part of Taxol
-tree bark
-prevents depolymerization of microtubules
-very lipohilic = insoluble in water
Cremophor EL
-part of taxol
-polyoxyetheylated castor oil
-non-ionic surfactant
Liposomes
-vesicular structures based on one or more lipid bilayers
-phospholipids and cholesterol
Phospholipids
-liposome
-natural or synthetic
-polar head nonpolar tail
-spontaneously arrange to form most stable bilayer structure
-flat bilayers self close into concentric compartments around a central aq phase to form liposomes
Doxil (DOXorubican In Liposome)
-HCl
-PEGylated liposomes
-hand-foot syndrome side effect
Doxil use
-ovarian cancer
-AIDS releated kaposi’s sarcoma
-multiple myeloma
PEGylated liposomes
-decorated w polyethylene glycol
-Caelyx
-DOxil
Protein nanoparticles
-Albumin
-Abraxane
Albumin
-carries hydroPHOBIC molecules in blood (vit, hormones)
-reversible binding
-endothelial transcytosis of bound drug
-preferential intratumoral accumulation of paclitaxel via binding to SPARN and EC matrix glycoprotein overexpressed in many cancers
