PARASITOLOGY Flashcards
Type of host where the parasite attains sexual maturity?
Definitive host
Type of host that harbors the asexual or larval stage.
Intermediate host
Type of host where the parasite does not develop but remains alive and can infect others.
Paratenic host
Type of host that allows the life cycle to continue and is a source of human infections.
Reservoir host
What is the vector for the trench fever?
Human body louse
What is the vector for the plague ?
Oriental rat flea (Xenopsylla cheopis)
What is the vector for relapsing fever from B. recurrentis?
Human body louse
What is the vector for chikungunya?
Aedes mosquito
What is the vector for dengue?
Aedes mosquito
The aedes mosquito is the vector of three important viral conditions.
- Dengue
- Yellow fever
- Chikungunya
Vector for Japanese encephalitis?
Culex
Vector for Malaria?
Anopheles
Vector for H. nana ?
Confused beetle (Tribolium confusum)
(Think Nana : Nani? )
Vector for Chagas disease?
- Kissing
- Reduviid
- Assassin bug
Vector for African sleeping sickness?
Tsetse fly (Glossina)
Vector for Kala-azar?
Leishmaniasis: Sandfly
Vector for Onchocerca volvulus?
Blackfly (Simulium)
Remember that the Onchocerca causes river blindness.
All you see is black = blackfly
Vector for Loa loa ?
Deer / Mango/ Horse fly (Chrysops)
Histopathology appearance of intestinal lesion caused by entamoeba histolytica?
Flask -shaped narrow necked ulcers
Compared to Balantidium coli, whose lesions appear as round based wide necked ulcers.
Most common location of E. histolytica in the intestines.
Cecum
Route of spread of E. histolytica to the liver?
Portal circulation
Microemboli that include trophozoites are carried through the portal circulation
Rare skin complication caused by E. histolytica?
Amoebiasis cutis - reddish painful ulcer with wine like inflammatory halo.
Luminal agents used in conjunction with tissue amebicides in amebic dysentery. (3)
- Dilaxonide furoate
- Iodoquinol
- Paromomycin
Common commensal Entamoeba species morphologically similar to E. histolytica but are non-pathogenic?
Entamoeba dispar
Specific diagnostic tool for Giardia lamblia.
Enterotest or Doudenal String Test
Stool characteristic of Giardiasis.
Steatorrheic
Free living soil amebae implicated in primary amebic meningoencephalitis (PAM) and granulomatous amebic encephalitis (GAE). (3)
- Naegleria fowleri
- Acanthamoeba castellanii
- Balamuthia mandrillaris
Gold standard in the diagnosis of Trichomoniasis vaginalis?
NAAT - Nucleic Acid Amplification Test
Characteristic internal examination finding in females with trichomoniasis.
Strawberry cervix
Presentation of trichomoniasis in males.
Prostatitis , Urethritis , thin white urethral discharge in 10% .
Trichomoniasis can also cause purulent penile discharge
Species causing cutaneous leishmaniasis confined to a single , indolent, ulcerative lesion that heals in about 1 year.
Leishmania mexicana
Vector of transmission for african tryponosomiasis.
Tsentse fly (Glossina)
Plasmodium species with hypnozoite forms in the liver. (2)
P. vivax & P. ovale
Reservoir of Balantidium coli.
Pigs
Drug used to kill schizonts in the liver.
Primaquine
Form of ascaris lumbricoides in the lungs.
Larvae
Infective stage of ascaris lumbricoides ?
Embryonated egg
Pathophysiology of acute appendicitis and acute pancreatitis in Ascariasis.
Migration of worms causing lumen blockage
Microscopic characteristic of trichuris trichiura eggs.
Barrel shape with two terminal polar plugs.
Microscopic characteristic of Capillaria philippinensis eggs.
Peanut shaped with triated shells and flattened bipolar plugs
Organisms causing a coconut cake appearance of the rectum.
Trichuris trichiura
Nematode whose adult forms resides in the host’s body cavities, most commonly in the peritoneal or pleural cavity.
Mansonella perstans
What are the 3 species of Mansonella and what area of body they reside?
- M. perstans- redides in body cavities
- M. ozzardi - subcutaneous tissue
- M. streptocerca - in the dermis
Culture for growing hookworms?
Harada -Mori culture
What are the intestinal nematodes residing in the large intestine? (2)
- Trichuris trichiura
- Entorobius vermicularis
(Large TE)
What are the intestinal nematodes residing in the small intestines ? (4)
- Capillaria
- Ascaris
- Strongyloides
- Hookworms
(Small CASH)
Intestinal nematode that can cause vulvovaginitis.
Entorobius vermicularis
Soil transmitted helminths. (4)
- Ascaris
- Trichuris
- Hookworms
- Strongyloides
Neurotransmitter involved in the drug of choice for Strongyloidiasis.
GABA
Nematode that undergo lung migration? (4)
- Ascaris lumbricoides
- Strongyloides stercoralis
- Hookworms: Necator Americanus , Ancylostoma duodenale
(ASH causes cough )
Organisms that cause auto infection. (6)
- Strongyloides stercoralis
- Hymenolepsis nana
- Capillaria philippinensis
- Enterobius vermicularis
- Cryptosporidium parvum
- Taenia solium
“ Some Helminths Can Enter the Colon Twice”
Diagnostic test of Wuchereria bancrofti and Brugia malayi.
Microfilariae
Cause of the most significant pathologies of schistosome infection.
Schistosome eggs
- the hundreds to thousands of eggs released by the female schistosome are swept by the circulation and lodge into the different organs. They cause a granulomatous reaction that surrounds them, leading to fibrosis.
Parasite that resides in both superior and inferior mesenteric veins of the small intestine?
Schistosoma japonicum
Parasite that resides in the inferior mesenteric veins of the large intestine?
S. mansoni
Parasite that resides in the veins of the urinary bladder
S. haematobium
Parasite associated with squamous cell carcinoma iof teh bladder?
S. haematobium
Parasitic infection that closely resembles pulmonary Tb and manifests as chronic cough with bloody sputum?
Paragonimiasis
Disease caused by Taenia solium when humans are its intermediate host.
Cysticercosis
Most pathogenic species of malaria.
P. falciparum
Identify the disease and pathogen:
Vaginal discharge, vulvar pruritus, watery, whitish urethral discharge.
Trichomoniasis - Trichomonas vaginalis
Smallest tapeworm infecting man.
Hymenolepis nana
Characteristics of Strongyloides. (4)
- Undergoes free-living life cycle in soil
- Produces filariform larvae
- Migrating larvae induce marked eosinophilia
- Infect by penetration of intact skin
Only infection of the reproductive tract caused by a protozoan.
Trichomoniasis
Parasite that produces stools that are steatorrheic or gruelly.
Giardia lamblia
Preferred test for detecting T. vaginalis with high sensitivity.
NAAT
Wet mounts are definitely convenient but they have low sensitivity
Ova that float in the saturated salt solution. (5)
Fertilized eggs of:
1. Enterobius vermicularis
2. Ascaris lumbricoides
3. Ancylostoma duodenale
4. Trichuris trichiura
5. Hymenolepis nana
Organism that can cause acalculous cholecystitis.
Malaria , due to increased hemolysis.
Enterobius belongs to which class of worm?
Nematode
Child from southern province thin with potbelly revealing microcytic, hypochromic anemia and fecal exam reveals brown , oval nematode eggs.
Ascaris lumbricoides
Infective stage in neurocysticercosis.
Embryonated egg
Infective stage in Taeniasis.
Cysticerci
Most common CC in Taeniasis.
Passage of proglottids or segments in stool.
Definitive host in Taeniasis?
Human
Humans are what type of host in cysticercosis?
Intermediate host (they harbor the larval state)
Management of Taeniasis?
Praziquantel
Which taenia can be acquired from ingestion of uncooked beef ?
T. saginata
Which Taenia can be acquired from ingestion of uncooked pork?
T. solium (pork tapeworm)
AKA fish tapeworm?
Diphyllobothrium latum
All cestode eggs are non-operculared except?
Diphyllobothrium latum
1st Intermediate host of D. latum?
Copepods
2nd Intermediate host of D. latum?
Dish
Hematologic abnormality associated with D. latum ?
Megaloblastic anemia ( Vit B12 deficiency)
Management of D. latum?
Praziquantel
Intermediate host of E. granulosus? (2)
Sheep and Man
Definitive host of E. granulosus?
Dog
Life threatening complications of rupture of E. granulosus cyst?
Anaphylaxis
Where are echinococcal cysts most commonly found?
In the liver (Inferior Right Lobe)
Triad of human cystic echinococcosis?
- Intermittent jaundice
- Fever
- Eosinophilia
What sign is seen in ultrasonography in echinococcosis?
Water Lilly Sign
Small fox tapeworm?
Echinococcus multilocularis
Dwarf tapeworm?
Hymenolepis nana
Treatment of choice in H. nana infections?
Praziquantel
Largest and longest tapeworm?
D. latum
Which major intestinal protozoans are acquired via drinking their cysts in contaminated water? (3)
- Giardia
- Entamoeba histolytica
- Cryptosporidium
Infective form of Entamoeba histolytica?
Quadrinucleated / Mature cyst
Habitat for all entamoeba in the GIT?
Cecum
Form of Entamoeba more seen in formed non-diarrheal stool?
Cyst
Form of Entamoeba more seen in diarrheal stool?
Trophozoite
Classic appearance of trophozoites in Entamoeba infection?
Contains ingested red blood cells ( Erythrophagocytosis)
Classic appearance of ulcers in Entamoeba infections?
Erlenmeyer flask ulcers ( due to lateral burrowing)
Protozoan that causes Erlenmeyer flask ulcers in the colon?
Entamoeba histolytica
Type of diarrhea caused by E. histolytica? ( bloody vs non-bloody)
Usually Bloody
Most common extraintestinal form of E. histolytica infections?
Amebic liver abscess
Most common cause of liver abscess in developing countries?
E. histolytica
Drug of choice for invasive amebiasis?
Metronidazole
Drug of choice for asymptomatic cyst passers of E. histolytica? (3)
- Diloxanide furoate
- Iodoquinol
- Paromomycin
Classic description of amebic liver abscess consistency?
Anchovy paste consistency
What causes primary amebic meningoencephalitis (PAM) ?
Naegleria fowleri
What causes secondary amebic meningoencephalitis (PAM) ?
Entamoeba histolytica
Etiology of granulomatous amebic encephalitis?
Acanthamoeba castellani
Where do humans usually acquire N. fowleri?
Warm fresh water ( hot springs)
How does N. fowleri enter the CNS?
Via the cribriform plate
Associated with amebic keratitis in contact lens wearers?
Acanthamoeba castellanii