Paraneoplastic Tumor Effects

Question 1

Cushing’s syndrome (Neoplasm/Hormone)

Answer 1

Neoplasm: Small cell carcinoma of the lung
Hormone: ACTH/ACTH-like peptide

Question 2

SIADH (Neoplasm/Hormone)

Answer 2

Neoplasm: Small cell carcinoma of the lung and intracranial neoplasms

Hormone: ADH

Question 3

Hypercalcemia (Neoplasm/Hormone)

Answer 3

Neoplasm: Small cell carcinoma of the lung, renal cell carcinoma, and breast carcinoma

Hormone: PTH-related peptide, TGF-b, TNF, IL-1

Question 4

Polycythemia (Neoplasm/Hormone)

Answer 4

Neoplasm: Renal cell carcinoma, hemangioblastoma, heptatocellcular carcinoma, pheochromocytoma

Hormone: EPO

Question 5

Lambert-Eaton Syndrome (Neoplasm/Hormone)

Answer 5

Neoplasm: Thymoma, small cell carcinsoma of the lung

Hormone: AB against presynaptic CA2+ channels at NMJ

Question 6

Gout/Urate Nephropathy (Neoplasm/Hormone)

Answer 6

Neoplasm: Leukemias and lymphomas

Hormone: Hyperuricemia due to excessive nucleic acid turnover (i.e. cytotoxic therapy)

Question 7

Small cell carcinoma of the lung

Answer 7

1 - Cushing’s syndrome (ACTH)
2 - SIADH
3 - Lambert-Eaton syndrome

Question 8

Intracranial neoplasms

Answer 8

SIADH

Question 9

Squamous cell carcinoma

Answer 9

Hypercalcemia

Question 10

Renal cell carcinoma

Answer 10

1 - Hypercalcemia

2 - Polycythemia (EPO)

Question 11

Breast carcinoma

Answer 11

Hypercalcemia

Question 12

Hepatocellular carcinoma

Answer 12

Polycythemia (EPO)

Question 13

Hemangioblastoma

Answer 13

Polycythemia (EPO)

Question 14

Pheochromocytoma

Answer 14

Polycythemia (EPO)

Question 15

Thymoma

Answer 15

Eaton-Lambert Syndrome

Question 16

Leukemia/Lymphoma

Answer 16

Gout/urate nephropathy