Mutations in Tumor Suppressor Genes (both alleles must be lost)

Question 1

RB (associated tumor and gene product)

Answer 1

Tumor: Retinoblastoma, osteosarcoma

Gene product: RB gene product blocks G1 > S phase of the cell cycle

Question 2

p-53 (associated tumor and gene product)

Answer 2

Tumor: Most human cancers; Li-Fraumeni syndrome

Gene product: p53 gene blocks G1 > S phase of the cell cycle

Question 3

BRCA-1 (associated tumor and gene product)

Answer 3

Tumor: Breast and ovarian cancer

Gene product: DNA repair protein

Question 4

BRCA-2 (associated tumor and gene product)

Answer 4

Tumor: Breast cancer

Gene product: DNA repair protein

Question 5

p16 (associated tumor and gene product)

Answer 5

Tumor: Melanoma

Gene product: N/A

Question 6

APC (associated tumor and gene product)

Answer 6

Tumor: Colorectal cancer (assoc w/ FAP)

Gene product: N/A

Question 7

WT1 (associated tumor and gene product)

Answer 7

Tumor: Wilm’s tumor

Gene product: N/A

Question 8

NF1 (associated tumor and gene product)

Answer 8

Tumor: Neurofibromatosis type 1

Gene product: N/A

Question 9

NF2 (associated tumor and gene product)

Answer 9

Tumor: Neurofibromatosis type 2

Gene product:

Question 10

DPC (associated tumor)

Answer 10

Tumor: Pancreatic cancer (DPC - ‘deleted in pancreatic cancer’)

Gene product: N/A

Question 11

DCC (associated tumor)

Answer 11

Tumor: Colon cancer (DCC - ‘deleted in colon cancer’)

Gene product: N/A