Mutations in Oncogenes (gain of function - damage to 1 allele)

Question 1

ABL

Answer 1

Tumor: CML

Gene product: Tyrosine kinase

Question 2

C-MYC

Answer 2

Tumor: Burkitt’s lymphoma

Gene product: Transcription factor

Question 3

BCL-2

Answer 3

Tumor: Follicular & undifferentiated lymphomas (inhibits apoptosis)

Gene product: Anti-apoptotic molecule

Question 4

ERB-B2

Answer 4

Tumor: Breast, ovarian and gastric carcinoma

Gene product: Tyrosine kinase

Question 5

RAS

Answer 5

Tumor: Colon carcinoma

Gene product: GTPase

Question 6

L-MYC

Answer 6

Tumor: Lung tumor

Gene product: Transcription factor

Question 7

N-MYC

Answer 7

Tumor: Neuroblastoma

Gene product: Transcription factor

Question 8

RET

Answer 8

Tumor: MEN 2A/2B

Gene product: Tyrosine kinase

Question 9

C-KIT

Answer 9

Tumor: GI stromal tumor (GIST)

Gene product: Cytokine receptor

Question 10

PDGFB

Answer 10

Tumor: astrocytoma

Gene product: platelet-derived growth factor

Question 11

CCND1 (cyclin D1)

Answer 11

Tumor: Mantle cell lymphoma

Gene product: cyclin

Question 12

CDK4

Answer 12

Tumor: melanoma

Gene product: cyclin-dependent kinase