Paraneoplastic Syndrome

Question 1

What are all the possible paraneoplastic syndromes due to carcinoma of the lungs?

Answer 1

1. Syndrome of inappropriate ADH secretion (ADH like protein production)
2. Cushing syndrome (ACTH like protein production)
3. Hypercalcemia (PTHrp)
4. Cerebellar degeneration (tumour toxic products)
5. Peripheral sensory & motor neuropathy
6. Proximal myopathy & dermatomyositis
7. Hypertrophic pulmonary osteoarthropathy/clubbing

Question 2

NSCLC: Squamous Cell Carcinoma produces which paraneoplastic syndromes?

Answer 2

Hypercalcemia

Question 3

SCLC: Small Cell Carcinoma produces which paraneoplastic syndromes?

Answer 3

1. Syndrome of inappropriate ADH secretion (ADH like protein production)
2. Cushing syndrome (ACTH like protein production)
3. Lambert-Eaton syndrome (myasthenia gravis-like illness resulting from defect in acetylcholine release)