Lung Cancer- Non Small Cell Lung cancer

Question 1

NSCLC types?

Answer 1

1. Squamous cell carcinoma
2. Adenocarcinoma
3. Bronchioloalveolar carcinoma
4. Large cell anaplastic carcinoma

Question 2

Squamous cell carcinoma gross fx?

Answer 2

Central location;

hilar mass with central necrosis and cavitation;

Large in size

Locally invasive

Question 3

Squamous cell carcinoma histo fx?

Answer 3

Squamous differentiation with

keratin pearls

Question 4

Squamous cell carcinoma clinical fx?

Answer 4

Metastasizes somewhat later

Question 5

Adenocarcinoma gross fx?

Answer 5

• Peripherally located (arising from alveolar septal cells or terminal bronchioles)
• Less rapid-growing than squamous cell carcinomas
• Scarring
• Pleural involvement

Question 6

Adenocarcinoma histo fx?

Answer 6

develops on scar site,

glandular elements with mucin cells

Question 7

Adenocarcinoma clinical fx?

Answer 7

Metastasizes readily

Question 8

Bronchioloalveolar carcinoma gross fx?

Answer 8

• Peripherally located (bronchioloalveolar regions)
• Multiple mucinous nodules (which appear on CXR)
• Pneumonia-like consolidation (as multiple diffuse nodules coalesce)

Question 9

Bronchioloalveolar carcinoma histo fx?

Answer 9

• Lepidic growth pattern
  􀂃 Growth along pre-existing structures without destruction of alveolar architecture
• Heterogeneous cellular make-up:
  􀂃 Mucin-secreting bronchiolar cells
  􀂃 Clara cells
  􀂃 Type II pneumocytes

Question 10

Bronchioloalveolar carcinoma clinical fx?

Answer 10

Good prognosis, well-differentiated, rare

Question 11

Large Cell Anaplastic Carcinoma gross fx?

Answer 11

Peripheral location;

Question 12

Large Cell Anaplastic Carcinoma histo fx?

Answer 12

1. Large polygonal undifferentiated cells (pleomorphic giant cells with leukocyte fragments in cytoplasm)
2. Large nuclei, prominent nucleoli,
   abundant cytoplasm, usually well-defined cell borders

Question 13

Large Cell Anaplastic Carcinoma variants?

Answer 13

• Giant cell carcinoma

- Clear cell carcinoma