Papulosquamous Dis Flashcards
HLA ass of psoriasis
HLA Cw6 with juvenile psoriasis
Hla b27 with psoriatic arthritis
Types of psoriasis
Guttata psoriasis- in children after URTI
C/f of psoriasis
Grattage test
Candle grease sign
Auspitz sign
Histology if psoriasis
- parakeratosis
- angranulosis
- acanthosis
- thinning of suprapapillary space
- dermal papillae enlarged
- dermal vs dilated and tortuous
- t cell infiltration
- Munro’s microabscess
- kogoj pustules
- squeezing out of cells
Cx of psoriasis
Pustular psoriasis
Generalised Cld von zumbasch dis
In pregnancy cld impetigo herpetiformis
Erythrodermic psoriasis
Topical Tt of psoriasis
Corticosteroids Keratolytics Salicylic acid Coal tar Dithranal Retinoids
Systemic tt of psoriasis
Methotrexate
Cyclosporine
Acitretinin
Phototherapy regimes in psoriasis
1) ingram regime - apply dithranal and light
2) grekerman regime - apply coal tar and light
Biological tt of psoriasis
- infliximab
- adalimumab
- etancerept
- efalizumab
- alefacept
- apremilast
- sekukinumab
- ustekinumab
Pityriasis rosea
Mc in females
Herald patch/ mother patch mc present on trunk
Ass with HHV 6,7
Cigarette paper scaling present
Fir tree appearance of lesion
On periphery lesions have collarette of scales
Hanging curtain sign
Lichen planus
Wickhams striae present over polygonal lesions Inv flexors Ass with hep B, C and primary biliary cirrhosis Koebner phenomena present Scarring alopecia 5ps - polygonal Papules Purple Painless
Nail changes in lichen planus
Dorsal Pterygium
Anonychia
Onychorexia
Histologic feature in lichen planus
Basal cell degeneration Colloid bodies/ clivette Pigment incontinence Melanophages Hypergranulosis Irregular acanthosis Lymphocytic infiltrate band in upper dermis Max Joseph spaces Saw tooth appearance of rete ridges Interface dermatitis
Tt of lichen planus
Steroid
Dapsone
Azathioprine
Phototherapy
