Blistering Dis and infections 1 Flashcards

1
Q

Drug induced Pemphigus by?

A
  • penicilamine
  • piroxicam
  • phenolphthalein
  • phenylbutazone
  • captopril
  • rifampicin
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2
Q

Paraneoplastic pemphigus by?

A
  • non Hodgkin lypmphoma
  • cll
  • castleman dis
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3
Q

Hla ass of pemphigus vulgaris

A

Hla DR-4

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4
Q

Ass of pemphigus foliaceous?

A
  • myasthenia gravis

- thymoma

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5
Q

Inv in pemphigus(p) vulgaris

A

Buccal mucosa
Scalp
Trunk
Extremities

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6
Q

Inv in p floiaceous

A

Upper trunk
(Presternal and interscapular area)
Lower trunk
Extremity

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7
Q

Clinical signs in pemphigus

A
  • nikolysky sign

- bullae spread sign or asboe Hansen sign

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8
Q

Histologic feature in pemphigus

A

Acanthocytes

Row of tombstone appearance

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9
Q

Direct if pattern in pemphigus

A

Fish net like pattern

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10
Q

Tt in pemphigus

A
  • cyclophosphamide
  • azathioprine
  • rituximab
  • ivig
  • plasmapheresis
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11
Q

Subcorneal bullae in

A

P foliaceous

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12
Q

Suprabasal bullae in

A

P vulgaris

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13
Q

Sub epidermal bullae in

A

Bullous pemphigoid

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14
Q

Histologic feature in bullous pemphigoid

A

Subepithelial Split with eosinophils collection

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15
Q

On dif in bullous pemphigoid

A

Linear if

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16
Q

Features of pemphigus

A
MINAR
Mucosal inv
Intraepidermal bullae
Nicolysky sign
Acanthocytes
Row of tombstone appearance
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17
Q

Tt of bullous pemphigoid

A

Steroids
Dapsone
Tetracycline

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18
Q

Hla ass of linear iga dis

A

Hla B8

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19
Q

Ch lesion in linear iga dis

A

Ring of pearl or string of pearl appearance

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20
Q

Dif in linear iga dis

A

Linear iga deposits along bmz

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21
Q

Tt of linear iga dis

A

Dapsone

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22
Q

Ass of dermatitis herpetiformis

A

Hla DQ2 /B8
Celiac dis
Antiendomysial ab
Antitransglutaminase ab

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23
Q

C/f of dermatitis herpetiformis

A

Extreme pruritic lesions over knee, elbow, back, buttock

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24
Q

Dif pattern of dermatitis herpetiformis

A

Granular iga deposits along BMZ in dermal papillae

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25
Q

Tt in dermatitis herpetiformis

A

Gluten free diet where avoid barley, rye, oat and wheat

Dapsone

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26
Q

Herpes gestationionalis feature

A
  • Linear c3 deposits > igG deposits along BMZ

- peri umbilical vesicular eruptions

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27
Q

Epidermolysis bullosaEB acquired

A

Ab against non collagenous domain of collagen 7

28
Q

Eb types

A

Eb simplex - k5-k14 def
Eb junctional- laminin def
Eb dystrophicns- collagen 7 def

29
Q

Darrirer dis

A
ATP2A2 def 
Inv seborrhoic areas 
V shaped nail 
Acanthocytes 
Dyskerstois 
Corp grains and corp rods
30
Q

Hailey hailey dis

A

ATP2C1 def
Inv intertrigonois areas
Longitudinal white bands on nails
Dilapidated brick wall appearance

31
Q

Erythema multiforme

A

Idiopathic > herpes simplex > drugs

Target lesion

32
Q

SJS

A

Skin inv <10% area

Target lesions

33
Q

Ten

A

Skin inv >30%

34
Q

Pseudo nicolsky sign in

A

SJS

TEN

35
Q

Carbamazepine induced SJS and TEN

A

HLA B 1502

36
Q

Resident flora on skin

A

Corynebacterium

Staph epidermidis

37
Q

Trichomycosis axillaris

A

Yellowish nodules over axilla

Bact infection by corynebacterium tenwis

38
Q

Erythrasma by

A

Corynebacterium minutissimum

Coral red colour flourescence in wood lamp

39
Q

Woods lamp

A

Wavelength - 365 nm (320-400nm)

Filter made of barium silicate with 9% nickel oxide

40
Q

Woods lamp colour

A

Tinea capitis- green
Pseudomonas- green
Pityriasis versicolor- yellow/ apple green
Erythrasma- coral red
Tetracycline stained teeth- yellow>orange
Sq cell CA- red
Vitiligo-white
Ash leaf macules - bluish white in tuberous sclerosis
Chromohidrosis- variable colour
Porphyria- pink

41
Q

Bullous impetigo

A
Staph aureus
Dsg 1 destroyed 
Mucosa not inv 
Common in children 
Dicloxacillin is tt
42
Q

Non bullous impetigo

A

By strep
CX is PSGN
erythromycin is tt

43
Q

Ecthyma (E)

A

E pyogeneicum- strep and staph
E gangrenosum- pseudomonas
E contagiosum- parapox virus or orf virus

44
Q

Erysipelas

A

By gabhs (group a beta hemolytic strep)
Lymphangitis
Margins are clear

45
Q

Cellulitis

A

By staph and strep
Lynphangitis less common
Borders are diffuse

46
Q

Milian ear sign in

A

Erysipelas

47
Q

Pityriasis versicolor

A

Malassezia globossa fb malassezia furfur

48
Q

Pityriasis versicolor

A

Nail stoke sign

On koh mount- spaghetti and meatball appearance or banana and grapes appearance

49
Q

Tinea nigra

A

By pheoaneleomyces werneckii

50
Q

Candidadiaisis

A

C albicans and c glabrata

51
Q

Perlaeck is

A

Candidal infection of angle of mouth

52
Q

Piedra

A

White - by trichosporon begelli
Axilla and pubic hair inv

Black - by piedra hortae
Scalp hair inv

Tt is terbenafine

53
Q

Kerion

A

Trichophyton mentagrophyte ectothrix

Pull test here

54
Q

Favus

A

Teichophyton scholenieii endothrix

Scutula formed here

55
Q

Black dot

A

Endothrix
Trichophyton tonsourens
Trichophyton violaceoum

56
Q

Grey patch

A

Microsporum Canis

57
Q

Tenia pedis mc site

A

4th web space interdigital

58
Q

Mc type of tenia unguim

A

Distal lateral subungual onychomycosis

59
Q

Mc ectothrix causing tenia capitis (Tc)

A

M canis

60
Q

Mc endothrix causing tc

A

Trichophyton tonsourns

61
Q

Mc sp causing tc in India

A

Trichophyton violacoeus

62
Q

Mc sp causing tc in west

A

T tonsourens

63
Q

Mc sp causing tc in world

A

M canis

64
Q

Doc for tc

A

Griseofulvin

65
Q
Mc sp causing 
T corporis
T crura 
T mannun 
T pedis 
 T unguim
A

Trichophyton rubrum

Where it’s doc is Terbinafine