Blistering Dis and infections 1 Flashcards
Drug induced Pemphigus by?
- penicilamine
- piroxicam
- phenolphthalein
- phenylbutazone
- captopril
- rifampicin
Paraneoplastic pemphigus by?
- non Hodgkin lypmphoma
- cll
- castleman dis
Hla ass of pemphigus vulgaris
Hla DR-4
Ass of pemphigus foliaceous?
- myasthenia gravis
- thymoma
Inv in pemphigus(p) vulgaris
Buccal mucosa
Scalp
Trunk
Extremities
Inv in p floiaceous
Upper trunk
(Presternal and interscapular area)
Lower trunk
Extremity
Clinical signs in pemphigus
- nikolysky sign
- bullae spread sign or asboe Hansen sign
Histologic feature in pemphigus
Acanthocytes
Row of tombstone appearance
Direct if pattern in pemphigus
Fish net like pattern
Tt in pemphigus
- cyclophosphamide
- azathioprine
- rituximab
- ivig
- plasmapheresis
Subcorneal bullae in
P foliaceous
Suprabasal bullae in
P vulgaris
Sub epidermal bullae in
Bullous pemphigoid
Histologic feature in bullous pemphigoid
Subepithelial Split with eosinophils collection
On dif in bullous pemphigoid
Linear if
Features of pemphigus
MINAR Mucosal inv Intraepidermal bullae Nicolysky sign Acanthocytes Row of tombstone appearance
Tt of bullous pemphigoid
Steroids
Dapsone
Tetracycline
Hla ass of linear iga dis
Hla B8
Ch lesion in linear iga dis
Ring of pearl or string of pearl appearance
Dif in linear iga dis
Linear iga deposits along bmz
Tt of linear iga dis
Dapsone
Ass of dermatitis herpetiformis
Hla DQ2 /B8
Celiac dis
Antiendomysial ab
Antitransglutaminase ab
C/f of dermatitis herpetiformis
Extreme pruritic lesions over knee, elbow, back, buttock
Dif pattern of dermatitis herpetiformis
Granular iga deposits along BMZ in dermal papillae
Tt in dermatitis herpetiformis
Gluten free diet where avoid barley, rye, oat and wheat
Dapsone
Herpes gestationionalis feature
- Linear c3 deposits > igG deposits along BMZ
- peri umbilical vesicular eruptions