- cyclophosphamide - azathioprine - rituximab - ivig - plasmapheresis

Blistering Dis and infections 1 Flashcards by Madiha k

Drug induced Pemphigus by?

penicilamine
piroxicam
phenolphthalein
phenylbutazone
captopril
rifampicin

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Paraneoplastic pemphigus by?

non Hodgkin lypmphoma
cll
castleman dis

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Hla ass of pemphigus vulgaris

Hla DR-4

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Ass of pemphigus foliaceous?

myasthenia gravis

- thymoma

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Inv in pemphigus(p) vulgaris

Buccal mucosa
Scalp
Trunk
Extremities

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Inv in p floiaceous

Upper trunk
(Presternal and interscapular area)
Lower trunk
Extremity

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Clinical signs in pemphigus

nikolysky sign

- bullae spread sign or asboe Hansen sign

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Histologic feature in pemphigus

Acanthocytes

Row of tombstone appearance

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Direct if pattern in pemphigus

Fish net like pattern

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Tt in pemphigus

cyclophosphamide
azathioprine
rituximab
ivig
plasmapheresis

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Subcorneal bullae in

P foliaceous

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Suprabasal bullae in

P vulgaris

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Sub epidermal bullae in

Bullous pemphigoid

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Histologic feature in bullous pemphigoid

Subepithelial Split with eosinophils collection

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On dif in bullous pemphigoid

Linear if

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Features of pemphigus

MINAR
Mucosal inv
Intraepidermal bullae
Nicolysky sign
Acanthocytes
Row of tombstone appearance

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Tt of bullous pemphigoid

Steroids
Dapsone
Tetracycline

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Hla ass of linear iga dis

Hla B8

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Ch lesion in linear iga dis

Ring of pearl or string of pearl appearance

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Dif in linear iga dis

Linear iga deposits along bmz

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Tt of linear iga dis

Dapsone

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Ass of dermatitis herpetiformis

Hla DQ2 /B8
Celiac dis
Antiendomysial ab
Antitransglutaminase ab

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C/f of dermatitis herpetiformis

Extreme pruritic lesions over knee, elbow, back, buttock

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Dif pattern of dermatitis herpetiformis

Granular iga deposits along BMZ in dermal papillae

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Tt in dermatitis herpetiformis

Gluten free diet where avoid barley, rye, oat and wheat | Dapsone

Herpes gestationionalis feature

- Linear c3 deposits > igG deposits along BMZ | - peri umbilical vesicular eruptions

Epidermolysis bullosaEB acquired

Ab against non collagenous domain of collagen 7

Eb types

Eb simplex - k5-k14 def Eb junctional- laminin def Eb dystrophicns- collagen 7 def

Darrirer dis

``` ATP2A2 def Inv seborrhoic areas V shaped nail Acanthocytes Dyskerstois Corp grains and corp rods ```

Hailey hailey dis

ATP2C1 def Inv intertrigonois areas Longitudinal white bands on nails Dilapidated brick wall appearance

Erythema multiforme

Idiopathic > herpes simplex > drugs | Target lesion

SJS

Skin inv <10% area | Target lesions

Ten

Skin inv >30%

Pseudo nicolsky sign in

SJS | TEN

Carbamazepine induced SJS and TEN

HLA B 1502

Resident flora on skin

Corynebacterium | Staph epidermidis

Trichomycosis axillaris

Yellowish nodules over axilla | Bact infection by corynebacterium tenwis

Erythrasma by

Corynebacterium minutissimum | Coral red colour flourescence in wood lamp

Woods lamp

Wavelength - 365 nm (320-400nm) | Filter made of barium silicate with 9% nickel oxide

Woods lamp colour

Tinea capitis- green Pseudomonas- green Pityriasis versicolor- yellow/ apple green Erythrasma- coral red Tetracycline stained teeth- yellow>orange Sq cell CA- red Vitiligo-white Ash leaf macules - bluish white in tuberous sclerosis Chromohidrosis- variable colour Porphyria- pink

Bullous impetigo

``` Staph aureus Dsg 1 destroyed Mucosa not inv Common in children Dicloxacillin is tt ```

Non bullous impetigo

By strep CX is PSGN erythromycin is tt

Ecthyma (E)

E pyogeneicum- strep and staph E gangrenosum- pseudomonas E contagiosum- parapox virus or orf virus

Erysipelas

By gabhs (group a beta hemolytic strep) Lymphangitis Margins are clear

Cellulitis

By staph and strep Lynphangitis less common Borders are diffuse

Milian ear sign in

Erysipelas

Pityriasis versicolor

Malassezia globossa fb malassezia furfur

Pityriasis versicolor

Nail stoke sign | On koh mount- spaghetti and meatball appearance or banana and grapes appearance

Tinea nigra

By pheoaneleomyces werneckii

Candidadiaisis

C albicans and c glabrata

Perlaeck is

Candidal infection of angle of mouth

Piedra

White - by trichosporon begelli Axilla and pubic hair inv Black - by piedra hortae Scalp hair inv Tt is terbenafine

Kerion

Trichophyton mentagrophyte ectothrix | Pull test here

Favus

Teichophyton scholenieii endothrix | Scutula formed here

Black dot

Endothrix Trichophyton tonsourens Trichophyton violaceoum

Grey patch

Microsporum Canis

Tenia pedis mc site

4th web space interdigital

Mc type of tenia unguim

Distal lateral subungual onychomycosis

Mc ectothrix causing tenia capitis (Tc)

M canis

Mc endothrix causing tc

Trichophyton tonsourns

Mc sp causing tc in India

Trichophyton violacoeus

Mc sp causing tc in west

T tonsourens

Mc sp causing tc in world

M canis

Doc for tc

Griseofulvin

``` Mc sp causing T corporis T crura T mannun T pedis T unguim ```

Trichophyton rubrum | Where it’s doc is Terbinafine