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Derma > General > Flashcards

General Flashcards

1
Q

Due to defect in melanocytes dis?

A

1) vitiligo
2) piebaldism
3) lentigens due to inc melanocytes

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2
Q

Due to defect in melanosomes dis?

A

1) tanning

2) nevus acromicus

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3
Q

Due to defect in melanogenesis dis?

A

1) melasma
2) freckles
3) albinism

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4
Q

Skin lesion in peutz jeughers?

A

Perioral lentigens

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5
Q

xeroderma pogmentosum, due to defect in?

A

DNA repair mechanism where nucleotide excision repair defect

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6
Q

Skin lesion in xeroderma pigmentosum?

A

1) Freckles

2) squamous cell ca

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7
Q

Ceruloderma due to defect in?

A

Defective migration of melanocytes to stratum Basale

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8
Q

Melanocytes derives from?

A

Neural crest cells

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9
Q

Merkel cells location?

A

In rete ridges in stratum basale

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10
Q

Langerhan cells present in

A

Stratum spinosum

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11
Q

Granules in langerhan cells

A

Birbeck granules - racquet shapes granules

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12
Q

Langerhan cells immunohistochemistry?

A

Positive for CD1a, CD207 (langerin), S100

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13
Q

Langerhan cells dec in

A

1) psoriasis

2) sarcoidosis

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14
Q

Langerhan cells inc in

A

Langerhan cell histiocytosis (LHC) or histiocytosis X

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15
Q

Types of LHC

A

1) eosinophilic granuloma
2) hand schuller Christian dis
3) Literer siwe dis
4) hashimoto pritzker dis

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16
Q

Lesions in eosinophilic granuloma?

A

Osteolytic lesions on temporoparietal skull

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17
Q

Triad in hand schuller Christian dis?

A

1) multiple bone defects
2) di
3) exophthalmos/ proptosis

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18
Q

Literer siwe dis clinical features?

A

1) Seborrhic dermatitis over
- scalp
- t zone
- nasolabial folds
- retroauricular area
- presternal area
- interscapular area
2) bone inv
3) hepatosplenomegaly
4) lymphadenopathy

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19
Q

LHC Age wise dis ?

A

Eosinophilic granuloma- <8y
Hand schuller Christian dis - <5y
Literer siwe dis- <2y
Hashimoto pritzker dis - since birth

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20
Q

Derivatives of cells of epidermis?

A

1) keratinocytes- ectoderm
2) melanocytes - neural crest cells
3) merkel cells - ectoderm>neural crest cell
4) langerhan cells - bone marrow

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21
Q

Epidermal turnover time?

A

52-75days (14+14+28)

22
Q

Epidermal turnover time dec in?

A

Psoriasis (4days)

23
Q

Desmosomes made of?

A

Desmosomal protein cld calcium dependant desmosomal Adhesion molecule

24
Q

Desmosomal protein belong to 3 types of gene family?

A

1) cadherin
2) plakin
3) armadillo

25
Q

Types of desmosomal protein?

A

1) desmoglein
2) desmocolin
3) desmoplakin
4) plakoglobin

26
Q

Granules in str granulosum?

A

Keratohyaline granules which synthesise filaggrin

27
Q

Membrane coating granules are cld

A

Odland bodies

28
Q

Odland bodies fncn

A

To syn lipid memb

29
Q

Due to def str granulosum dis?

A

1) icthyosis vulgaris (autosomal dominant)
Due to def fliaggrin
2) asteototic eczema (due to old age or cold)

30
Q

Str lucidum translucent due to?

A

Elaidin refractive protein

31
Q

Str lucidum present in?

A

Palms and soles

32
Q

Parakeratosis seen in? (Presence of nucleus in str corneum)

A

1) psoriasis
2) eczema
3) actinic keratosis
4) seborrhic dermatitis
5) sq cell CA

33
Q

Dyskeratosis seen in?

A

1) sq cell CA
2) Bowen dis
3) pagets dis
4) hailey hailey dis
5) darrier dis

34
Q

In acute eczema, histology seen is?

A

Spongiosis and ballooning

35
Q

In chronic eczema, histologic feature seen is?

A

Acanthosis

36
Q

Regular acanthosis in?

A

Psoriasis

Chronic eczema

37
Q

Irregular ancanthosis in

A

Lichen planus

38
Q

Histology in lichen planus?

A

Irregular acanthosis

Hypergranulosis

39
Q

Histologic feature in psoriasis

A

Angranulosis

Regular acanthosis

40
Q

Neutrophilic microabsecc in

A

Cld papillary tip microabscess seen in dermatitis herpetiformis

41
Q

In psoriasis, microabscess seen?

A

Munro microabscess

Kogoj pustules

42
Q

Lymphocytic microabscess in

A

Also cld pautrier m/a seen in mycosis fungoides

43
Q

Eosinophilic microabscess in?

A

Also cld intraepidermal eosinophilic m/a seen in pemphigus vegetans

44
Q

Defect in BPAG1/BP230 Lead to?

A
  • bullous pemphigoid

- dermatitis herpetiformis

45
Q

Defect in BPAG2/BP180 lead to?

A
  • Bullous pemphigoid
  • herpes gestationalis
  • linear IgA dis
  • lichen planus pemphigoides
46
Q

Defect in collagen 7 lead to?

A

Epidermolysis bullosa dystrophicans

47
Q

Collagen in dermis?

A

Type 1 and type 3

48
Q

Str corneum becomes in preterm develops within?

A

2-3 weeks postnatal

49
Q

Malpighian layer of epidermis?

A

Str basale + str spinosum

50
Q

Integumentary system has?

A 
Skin
Hair
Nails
Glands
Subcutaneous tissue
51
Q

Mutations in desmosomes are the main cause of

A

Arrythmogenic right ventricular cardiomyopathy

Derma (6 decks)

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