General Flashcards
Due to defect in melanocytes dis?
1) vitiligo
2) piebaldism
3) lentigens due to inc melanocytes
Due to defect in melanosomes dis?
1) tanning
2) nevus acromicus
Due to defect in melanogenesis dis?
1) melasma
2) freckles
3) albinism
Skin lesion in peutz jeughers?
Perioral lentigens
xeroderma pogmentosum, due to defect in?
DNA repair mechanism where nucleotide excision repair defect
Skin lesion in xeroderma pigmentosum?
1) Freckles
2) squamous cell ca
Ceruloderma due to defect in?
Defective migration of melanocytes to stratum Basale
Melanocytes derives from?
Neural crest cells
Merkel cells location?
In rete ridges in stratum basale
Langerhan cells present in
Stratum spinosum
Granules in langerhan cells
Birbeck granules - racquet shapes granules
Langerhan cells immunohistochemistry?
Positive for CD1a, CD207 (langerin), S100
Langerhan cells dec in
1) psoriasis
2) sarcoidosis
Langerhan cells inc in
Langerhan cell histiocytosis (LHC) or histiocytosis X
Types of LHC
1) eosinophilic granuloma
2) hand schuller Christian dis
3) Literer siwe dis
4) hashimoto pritzker dis
Lesions in eosinophilic granuloma?
Osteolytic lesions on temporoparietal skull
Triad in hand schuller Christian dis?
1) multiple bone defects
2) di
3) exophthalmos/ proptosis
Literer siwe dis clinical features?
1) Seborrhic dermatitis over
- scalp
- t zone
- nasolabial folds
- retroauricular area
- presternal area
- interscapular area
2) bone inv
3) hepatosplenomegaly
4) lymphadenopathy
LHC Age wise dis ?
Eosinophilic granuloma- <8y
Hand schuller Christian dis - <5y
Literer siwe dis- <2y
Hashimoto pritzker dis - since birth
Derivatives of cells of epidermis?
1) keratinocytes- ectoderm
2) melanocytes - neural crest cells
3) merkel cells - ectoderm>neural crest cell
4) langerhan cells - bone marrow
Epidermal turnover time?
52-75days (14+14+28)
Epidermal turnover time dec in?
Psoriasis (4days)
Desmosomes made of?
Desmosomal protein cld calcium dependant desmosomal Adhesion molecule
Desmosomal protein belong to 3 types of gene family?
1) cadherin
2) plakin
3) armadillo
Types of desmosomal protein?
1) desmoglein
2) desmocolin
3) desmoplakin
4) plakoglobin
Granules in str granulosum?
Keratohyaline granules which synthesise filaggrin
Membrane coating granules are cld
Odland bodies
Odland bodies fncn
To syn lipid memb
Due to def str granulosum dis?
1) icthyosis vulgaris (autosomal dominant)
Due to def fliaggrin
2) asteototic eczema (due to old age or cold)
Str lucidum translucent due to?
Elaidin refractive protein
Str lucidum present in?
Palms and soles
Parakeratosis seen in? (Presence of nucleus in str corneum)
1) psoriasis
2) eczema
3) actinic keratosis
4) seborrhic dermatitis
5) sq cell CA
Dyskeratosis seen in?
1) sq cell CA
2) Bowen dis
3) pagets dis
4) hailey hailey dis
5) darrier dis
In acute eczema, histology seen is?
Spongiosis and ballooning
In chronic eczema, histologic feature seen is?
Acanthosis
Regular acanthosis in?
Psoriasis
Chronic eczema
Irregular ancanthosis in
Lichen planus
Histology in lichen planus?
Irregular acanthosis
Hypergranulosis
Histologic feature in psoriasis
Angranulosis
Regular acanthosis
Neutrophilic microabsecc in
Cld papillary tip microabscess seen in dermatitis herpetiformis
In psoriasis, microabscess seen?
Munro microabscess
Kogoj pustules
Lymphocytic microabscess in
Also cld pautrier m/a seen in mycosis fungoides
Eosinophilic microabscess in?
Also cld intraepidermal eosinophilic m/a seen in pemphigus vegetans
Defect in BPAG1/BP230 Lead to?
- bullous pemphigoid
- dermatitis herpetiformis
Defect in BPAG2/BP180 lead to?
- Bullous pemphigoid
- herpes gestationalis
- linear IgA dis
- lichen planus pemphigoides
Defect in collagen 7 lead to?
Epidermolysis bullosa dystrophicans
Collagen in dermis?
Type 1 and type 3
Str corneum becomes in preterm develops within?
2-3 weeks postnatal
Malpighian layer of epidermis?
Str basale + str spinosum
Integumentary system has?
Skin Hair Nails Glands Subcutaneous tissue
Mutations in desmosomes are the main cause of
Arrythmogenic right ventricular cardiomyopathy
