Pancreas

Question 1

Which of the following is false regarding the anatomy of the pancreas
A. The left limb is contained within the dorsal leaf of the omentum
B. The endocrine portion of the pancreas only occupies 2% of the total pancreatic mass
C. The duct of Santorini (accessory pancreatic duct) empties into the duodenum at the minor duodenal papilla and the duct of Wirsung (pancreatic duct) enters the duodenum at the major duodenal papilla
D. Three distinct polypeptide secreting islet cells make up the endocrine secreting portion of the pancreas

Answer 1

D = 4

• Alpha cells = glucagon
• Beta cells = insulin
• Delta cells = somatostatin
• F or PP cells = pancreatic polypeptide

Question 2

True/False: The functional units of the pancreas are the acinar cells and islet cells which regulate glucose metabolism and digestion

Answer 2

true

Question 3

Which is FASLE for glucagonoma?
A Chief complaint in affected dogs is superficial necrolytic dermatitis.
B Diagnosis is based on increased serum glucagon, or immunohistochemical staining of histologic biopsies that is positive for glucagon
C Metastases is more common to the liver and lymph nodes
D Treatment of choice is surgical resection, reported cases have been treated successfully.

Answer 3

D Treatment of choice is surgical resection; however, the high rate of surgical complications and early metastasis lead to a poor prognosis.

A a condition more often associated with advanced liver disease and termed hepatocutaneous syndrome

Question 4

Which path does the majority of pancreatic secretions take to SI in dogs?

Answer 4

Right+ left limb –> duct of santorinin=acessory duct –> minor papilla

Question 5

How do alpha -2 agonists affect blood sugar?

Answer 5

hyperglycemia (hypoinsulinemia)

Question 6

T/F: The pancreatic inflammatory cascade is always irreversible

Answer 6

False

may progress to necrotizing pancreatitis, chronic –> parenchymal destruction and fibrosis

Question 7

What is the major blood supply to the left limb of the pancreas?

Answer 7

Celiac artery to splenic artery

Hepatic to pancreaticoduodenal for right limb

Question 8

Where is intrinsic factor produced?

Answer 8

Exocrine Pancreatic ductal cells

Along with bicarbonate, water, and antibacterial proteins

Question 9

What membrane does the left and right body of the pancreas live?

Answer 9

R=. Mesoduodenum

L = dorsal leaf of greater omentum

Question 10

What tumor results from transformation of delta islet cells?

Answer 10

Somatostatin to gastric secretion= gastrinoma

Question 11

What is Zollinger-Ellison syndrome?

Answer 11

Combination of non-beta neuroendocrine pancreatic tumor, hypergastrinemia, and gi ulceration