Palliative + One Flashcards
intracranial causes of nausea and vomiting - management
cyclizine
gastro-intestinal pain in palliative care.
domperidone
acute migraine, chemotherapy or radiotherapy-induced nausea and vomiting. It is a prokinetic agent which is unlikely to provide relief from nausea related to increased intracranial pressure.
metoclopramide
chemotherapy antiemetic
ondanstetron
Li-Fraumeni Syndrome
what gene? (1)
what cancers? (2)
p53 tumour suppressor gene
sarcomas leukaemia
BRAC 1 and 2 - what genes? 92)
which cancers? (3)
chromosome 17 (BRCA 1) and 13 (BRCA 2)
ovarian cancer
breast cancer
prostate cancer
Lynch syndrome:
how inherited? (1)
what type of cancer (2)
autosomal dominant
colon and endometrial cancer
What is the Amsterdam criteria? (1)
Used to identify Lunch
Three or more family members with a confirmed diagnosis of colorectal cancer, one of whom is a first degree (parent, child, sibling) relative of the other two.
Two successive affected generations.
One or more colon cancers diagnosed under age 50 years.
Familial adenomatous polyposis (FAP) has been excluded.
gardeners syndrome
Autosomal dominant familial colorectal polyposis
Multiple colonic polyps
Extra colonic diseases include: skull osteoma, thyroid cancer and epidermoid cysts
Desmoid tumours are seen in 15%
Mutation of APC gene located on chromosome 5
Due to colonic polyps most patients will undergo colectomy to reduce risk of colorectal cancer
Now considered a variant of familial adenomatous polyposis coli
Adverse effects of chemotherapy:
Bleomycin? (1)
lung fibrosis
Adverse effects of chemotherapy:
anthracyclines (doxorubicin)
cardiomyopathy
Adverse effects of chemotherapy: methotrexate
myelosuppression, mucositis, liver fibrosis, lung fibrosis
Adverse effects of chemotherapy: cisplatin
nephrotoxicity, ototoxicity, peripheral neuropathy, hypomagnaesia
