Pain study guide Flashcards
1
Q
MOA for opioids
A
Interact with opioid receptors (mu & kappa)
2
Q
3 main types of drug receptor interactions
A
- Opioid agonist (mu and kappa activated)
- Opioid antagonist (mu and kappa blocked)
- Mixed opioid agonist-antagonist (one blocked, one activated)
3
Q
MOA for NSAIDs
A
- Inhibit cyclooxygenase (COX 1 & 2)
- Peripherally acting at nociceptors
- COX break down arachidonic acid to prostaglandins, which induce pain, NSAIDs block it (enzymes from converting to prostaglandins)
4
Q
When are adjuvants needed?
A
- Refractory to opioids
- Neuropathic pain
- Can be used alone or in combination with opioids
5
Q
MOA for COX 2 Inhibitors
A
-ONLY blocks COX 2
6
Q
COX 2 Inhibitor drug
A
Celecoxib (Celebrex)
7
Q
Route for Fentanyl (Sublimaze)
A
IM, IV, transdermal
8
Q
Route for Hydromorphone (Dilaudid)
A
PO, SQ, IM, IV
9
Q
Route for Levorphanol (LevoDromoran)
A
PO, SQ, IV
10
Q
Route for Meperidine (Demerol)
A
PO, IM, IV
11
Q
Route for Methadone (Dolophine)
A
PO
12
Q
Route for Morphine
A
PO, IM, IV
13
Q
Route for Oxymorphone (Opana)
A
SQ, Rectal, PO
14
Q
Route for Codeine
A
PO, IM
15
Q
Hydrocodone (Hycodan)
A
PO
