pain proprioception Flashcards
nociceptors are
detector portions of pain afferent nerves
TPRV-1 mediates
hot peppers
pain for moderate ehat
pain from acidic environments
nociceptor afferent nerves require
more stimulus energy
and are tonic receptors
a delta fiebrs
large diameter with myelination and rapid conduction velocity
fast or first pain
inhibition of C fibers
Adelta HTM fibers synapse on
secondary nerves
c fibers
small diameter and no myelination
slow conduction velocity
70% of all pain fibers
c fibers stimulated by
thermal, mechanical, chemical stimuli
ischemia
c fiber stimulation pain perception is
dull achy burning
primary hyperalgesia is
increased pain responses at the site of the trauma
hyperalgesia is enhanced by
inflammation
inflammatory chemicals induce
vasodilation
classic signs of inflammation
dolar, ruber, calor, tumor
secondary hyperalgesia
released transmitters diffuse for some distance and stimulate pain nerve endings from nearby areas uninvolved with trauma
2 receptors that glutamte stimulates
AMPA NMDA
in short duration, small area trauma, mainly ___ receptors are activated in ___ nerves
AMPA and secondary
AMPA receptors normally stimulated by
low concentration of glutamate during acute pain
early LTP is initiated if
if pain felt for 30 min following initial stimulus
late LTP initiated if
if pain persists for days or more
involves protein synthesis
windup increases secondary nerve activating cascase that
induces early LPT
allodynia
pain due to stimulus that doesnt normally provoke pain
inhibiting what cells blocks chronic pain
A11 cells that secrete dopamine
neuropathic pain characterized by appearance of
dysasthesias (abnormal sensations)
CRPS I
reflex sympathetic distrophy
no obvious neural damage
CRPS II
involves nerve injury