Pain Management Flashcards

1
Q

2 major types of pain

A
  • nociceptive

- neuropathic

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2
Q

Denifition of nociceptive pain

A

Normal pain processing that occurs when free nerve endings are activated by tissue damage or inflammation

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3
Q

4 processes of nociceptive pain

A
  • transduction
  • transmission
  • perception
  • modulation
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4
Q

Definition of neuropathic pain

A

Abnormal processing of stimuli from the PNS or CNS that serves no useful purpose

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5
Q

Types of pain assessment tools

A
  • universal pain assessment tool
  • pain rating scale
  • visual analogue scale
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6
Q

Types of adjuvant pain medications

A
  • TCAs

- Anticonvulsants

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7
Q

TCAs used in pain control

A
  • amitryptyline

- Imipramine

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8
Q

Anticonvulsatns used in pain control

A
  • carbamazepine
  • valproic acid
  • gabapentin
  • pregabalin
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9
Q

MOA of paracetamol

A

Inhibitrs prostaglandin synthesis centrally

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10
Q

Cautions for paracetamol use

A
  • overdose = liver failure (NAPQI = toxic)
  • nephropathy with chronic use
  • caution in renal and hepatic impairment
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11
Q

Classification of NSAIDs

A
  • COX-1 selective
  • Non-selective
  • COX-2 selective
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12
Q

Contra-indications for NSAIDS

A
  • hypersensitivity

- acute PUD

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13
Q

Cautions for NSAIDS

A
  • renal and hepatic impairment
  • dyspepsia
  • cardiac failure
  • hypertension
  • bleeding disorders
  • asthma
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14
Q

Features of selective COX-2 inhibitors

A
  • less GI effects
  • increased CVS risk
  • needs to be taken with meals
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15
Q

Adverse effects of NSAIDS

A
  • bronchoconstriction
  • fluid retention
  • nephropathy and ARF
  • bleeding
  • hypersensitivity
  • dyspepsia and PUD
  • hepatotoxicity
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16
Q

AE of opioids

A
  • nausea
  • sedation
  • constipation
  • respiratory depression
17
Q

MOA of morphine

A
  • affinity for u receptors

- histamine release

18
Q

MOA of tramadol

A
  • u receptor agonist

- inhibit seotonin and noradrenalin reuptake

19
Q

Definition of chronic pain`

A

Pain lasting beyond the term of an injury or painful stimulus, present for more than 4-6 weeks

20
Q

WHO pain relief ladder

A
  • non-opioid
  • weak opioids
  • strong opioids
21
Q

Cautions for morphine

A
  • renal and hepatic impairment
  • elderly
  • pregnant
  • lactation
  • neonates
  • decreased pulmonary reserve
22
Q

Dose of morphine

A

10mg 4 hrly for 24 hours

23
Q

Drug interactions with tramadol

A
  • predisposes to serotonin syndrome when combined with SSRIs/ MAOIs
  • metabolism induced by carbamazepine
24
Q

Dose of tramadol

A

50mg 4-6 hrly, max 400mg/day

25
Q

Dose of codeine

A

30-60mg 4-6 hrly

26
Q

Describe variable metabolism of codeine

A

CYP2D6 variants

  • slow metabolisers (poor analgesic effect, but constipation)
  • rapid metabolisers (resp depression, coma and death)
27
Q

Dose of amitryptyline

A

10-25mg nocte