ARVs Flashcards
1
Q
Nucleotide reverse transcriptase inhibitors
A
- Tenofovir
- emtricitabine
- abacavir
- lamivudine
- zidovudine
- stavudine
- didanosine
2
Q
Non-nucleotide reverse transcriptase inhibitors
A
- efavirenz
- nevirapine
3
Q
Protease inhibitors
A
- lopinavir
- atazanavir
- darunavir
4
Q
Integrase inhibitors
A
- raltegravir
- dolutegravir
5
Q
Thymidine analogues
A
- zidovudine
- stavudine
6
Q
AEs of zidovudine
A
BM suppression
- anaemia
- neutropenia
- nausea
- headache
- myalgia
7
Q
AEs of tenofovir
A
- renal toxicity
8
Q
AEs of emtricitabine
A
- hyperpigmentation
9
Q
AEs of didanosine
A
- pancreatitis
- peripheral neuropathy
- horrible taste
10
Q
AEs of stavudine
A
- peripheral neuropathy
- hepatitis
11
Q
AE of abacavir
A
- hypersensitivity reaction
12
Q
Symptoms and signs of hyperlactataemia
A
- abdo discomfort/ LOW
- peripheral neuropathy
- hepatic steatosis
- tachycardia
- SOB
13
Q
AEs of nevirapine
A
- rash
- hepatitis
14
Q
AEs of efavirenz
A
- neuro stiff
- maculopapular rash
- teratogenic
15
Q
General AEs of PIs
A
- diarrhoea
- hepatitis
- hyperlipidaemia (not TG)
16
Q
AE of atazanavir
A
- hyperbilirubinaemia (unconj)
17
Q
AEs of integrase inhibitors
A
- insomnia
- decreased WCC
- raised LFTs
18
Q
Definition of first line failure
A
- 2 consecutive viral loads >1000 copies/ml
19
Q
Drugs with high resistance
A
- efavirenz
- nevirapine
- lamivudine
- emtricitabine
20
Q
CYTp450 inducers
A
- nevirapine
- efavirenz
- rifampicin
21
Q
CYPTp450 inhibitor
A
- protease inhibiotrs
