ARVs Flashcards

1
Q

Nucleotide reverse transcriptase inhibitors

A
  • Tenofovir
  • emtricitabine
  • abacavir
  • lamivudine
  • zidovudine
  • stavudine
  • didanosine
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2
Q

Non-nucleotide reverse transcriptase inhibitors

A
  • efavirenz

- nevirapine

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3
Q

Protease inhibitors

A
  • lopinavir
  • atazanavir
  • darunavir
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4
Q

Integrase inhibitors

A
  • raltegravir

- dolutegravir

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5
Q

Thymidine analogues

A
  • zidovudine

- stavudine

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6
Q

AEs of zidovudine

A

BM suppression

  • anaemia
  • neutropenia
  • nausea
  • headache
  • myalgia
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7
Q

AEs of tenofovir

A
  • renal toxicity
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8
Q

AEs of emtricitabine

A
  • hyperpigmentation
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9
Q

AEs of didanosine

A
  • pancreatitis
  • peripheral neuropathy
  • horrible taste
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10
Q

AEs of stavudine

A
  • peripheral neuropathy

- hepatitis

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11
Q

AE of abacavir

A
  • hypersensitivity reaction
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12
Q

Symptoms and signs of hyperlactataemia

A
  • abdo discomfort/ LOW
  • peripheral neuropathy
  • hepatic steatosis
  • tachycardia
  • SOB
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13
Q

AEs of nevirapine

A
  • rash

- hepatitis

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14
Q

AEs of efavirenz

A
  • neuro stiff
  • maculopapular rash
  • teratogenic
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15
Q

General AEs of PIs

A
  • diarrhoea
  • hepatitis
  • hyperlipidaemia (not TG)
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16
Q

AE of atazanavir

A
  • hyperbilirubinaemia (unconj)
17
Q

AEs of integrase inhibitors

A
  • insomnia
  • decreased WCC
  • raised LFTs
18
Q

Definition of first line failure

A
  • 2 consecutive viral loads >1000 copies/ml
19
Q

Drugs with high resistance

A
  • efavirenz
  • nevirapine
  • lamivudine
  • emtricitabine
20
Q

CYTp450 inducers

A
  • nevirapine
  • efavirenz
  • rifampicin
21
Q

CYPTp450 inhibitor

A
  • protease inhibiotrs