Anti-coagulation Flashcards
1
Q
Indications of a PE
A
- D-dimer
- Wells score
- S1Q3T3 (RV strain pattern on ECG)
2
Q
Problems with LMWH
A
- can’t give it to people at risk of bleeding, because you can’t stop the bleeding
3
Q
MOA of LMWH
A
Affects factor 10A
4
Q
WHo do you need to monitor with LMWH?
A
- pregnant women with valvular heart disease
5
Q
MOA of unfractionated heparin
A
- potentiates anti-thrombin 3
6
Q
Monitoring required for unfractionated heparin
A
PTT monitoring
7
Q
How to reverse unfractionated heparin
A
Protamine sulphate
8
Q
How is unfractionated heparin given?
A
IV infusion
9
Q
Adverse effects of unfractionated heparin
A
- > 5 days, heparin induced thrombocytopenia
- osteoporosis if longterm (dialysis patients)
10
Q
Why give heparin before warfarin?
A
- warfarin takes 48-72 hrs to work
11
Q
MOA of warfarin
A
Vit K antagonist
12
Q
AE of warfarin
A
- bleeding
- warfarin skin necrosis
- purple toe syndrome (cholesterol emboli)
13
Q
Causes of thrombophilai
A
- Factor 5 leiden
- Protein C+S def
- antiphospholipid syndrome
14
Q
How to reverse warfarin
A
- Vit K
- FFP
15
Q
Problems with warfatin
A
Lots of drug-drug interactions
- Rif
- NSAIDS
- alcohol
- diet
16
Q
What to do if they bleed while on warfarin
A
- stop warfarin
- IV VIT K
17
Q
What to do if they are warfarin toxic, but not bleeding
A
- give oral Vit K (1-2mg)
18
Q
How to manage HIT
A
- hiridin (thombin inhibitor (direct)
